Relationship Between Heart Rate Variability and Angiotensinogen Gene Polymorphism in Diabetic and Control Individuals

Faezeh Marzbanrad, Brett Hambly, Ethan Ng, Mikhail Tamayo, Slade Matthews, Chandan Karmakar, Ahsan H Khandoker, Marimuthu Palaniswami, Herbert Jelinek

Research output: Book chapter/Published conference paperConference paper

2 Citations (Scopus)

Abstract

Heart Rate Variability (HRV) is extensively used to investigate general Autonomic Nervous System (ANS) function and is affected by many factors including age, gender, pathology such as diabetes and genetic polymorphisms. One of these genetic polymorphisms is the Angiotensin Converting Enzyme (ACE) polymorphism corresponding to insertion (I) or deletion (D) of a 287-base pair sequence of DNA in intron 16 of the ACE gene (rs4340). Some studies have addressed the relationship between HRV and D/D, I/D and I/I ACE polymorphism while others combined I/D and I/I ACE groups. In this study HRV is determined for diabetic and control individuals with different ACE polymorphism considering either separate or combined I/D and I/I genotypes. Linear time domain parameters, entropy, low frequency and total power of HRV were found to be significantly different between diabetic and control individuals with combined I/I and I/D ACE polymorphism, while only entropy was different for diabetic and control subjects with D/D ACE genotype. Separate analysis of I/I and I/D genotypes was preferred for a thorough investigation of HRV and ACE polymorphism, as the combined analysis masked some differences in HRV parameters such as Poincaré plot between ACE polymorphisms and diabetes status. Furthermore, a separate analysis demonstrated that most of the significant differences for HRV were between the diabetic group with I/I genotype and I/D and D/D groups.
Original languageEnglish
Title of host publicationProceedings of the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages6683-6686
Number of pages4
ISBN (Electronic)9781424479290
DOIs
Publication statusPublished - 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Sheraton Hotel & Towers, Chicago, United States
Duration: 26 Aug 201430 Aug 2014
https://web.archive.org/web/20140621102347/http://embc.embs.org/2014/ (Archived page)

Conference

Conference2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Abbreviated titleDiscovering, Innovating, and Engineering Future Biomedicine
CountryUnited States
CityChicago
Period26/08/1430/08/14
Internet address

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  • Cite this

    Marzbanrad, F., Hambly, B., Ng, E., Tamayo, M., Matthews, S., Karmakar, C., Khandoker, A. H., Palaniswami, M., & Jelinek, H. (2014). Relationship Between Heart Rate Variability and Angiotensinogen Gene Polymorphism in Diabetic and Control Individuals. In Proceedings of the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 6683-6686). [ 6945161] IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2014.6945161