Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients

Xia-Feng Yang, Yuan-Zhi Chen, Jiang-Li Su, Feng-Yun Wang, Lexin Wang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3%) and myocardial infarction (13.5%) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2% and 6.2% respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95% CI, 0.28 to 0.71; P<0.01) and 0.66 (95% CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95% CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95% CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.
Original languageEnglish
Pages (from-to)1595-1599
Number of pages5
JournalJAMA Internal Medicine
Volume48
Issue number18
DOIs
Publication statusPublished - 2009

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Carotid Artery Diseases
Bilirubin
Serum
C-Reactive Protein
Atherosclerosis
Stroke
Odds Ratio
Myocardial Infarction
Blood Pressure
Hypertension
Carotid Stenosis
Carotid Arteries
Blood Proteins
Ultrasonography
Cholesterol

Cite this

Yang, Xia-Feng ; Chen, Yuan-Zhi ; Su, Jiang-Li ; Wang, Feng-Yun ; Wang, Lexin. / Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients. In: JAMA Internal Medicine. 2009 ; Vol. 48, No. 18. pp. 1595-1599.
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abstract = "Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3{\%}) and myocardial infarction (13.5{\%}) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2{\%} and 6.2{\%} respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95{\%} CI, 0.28 to 0.71; P<0.01) and 0.66 (95{\%} CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95{\%} CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95{\%} CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.",
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Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients. / Yang, Xia-Feng; Chen, Yuan-Zhi; Su, Jiang-Li; Wang, Feng-Yun; Wang, Lexin.

In: JAMA Internal Medicine, Vol. 48, No. 18, 2009, p. 1595-1599.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients

AU - Yang, Xia-Feng

AU - Chen, Yuan-Zhi

AU - Su, Jiang-Li

AU - Wang, Feng-Yun

AU - Wang, Lexin

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Archives of Internal Medicine. ISSNs: 0003-9926;

PY - 2009

Y1 - 2009

N2 - Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3%) and myocardial infarction (13.5%) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2% and 6.2% respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95% CI, 0.28 to 0.71; P<0.01) and 0.66 (95% CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95% CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95% CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.

AB - Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3%) and myocardial infarction (13.5%) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2% and 6.2% respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95% CI, 0.28 to 0.71; P<0.01) and 0.66 (95% CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95% CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95% CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.

KW - Atherosclerosis

KW - Bilirubin

KW - C-reactive protein

KW - Carotid plaque

KW - Hypertension

U2 - 10.2169/internalmedicine.48.2286

DO - 10.2169/internalmedicine.48.2286

M3 - Article

VL - 48

SP - 1595

EP - 1599

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 18

ER -