Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1595-1599 |
| Number of pages | 5 |
| Journal | JAMA Internal Medicine |
| Volume | 48 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2009 |
Fingerprint
Cite this
}
Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients. / Yang, Xia-Feng; Chen, Yuan-Zhi; Su, Jiang-Li; Wang, Feng-Yun; Wang, Lexin.
In: JAMA Internal Medicine, Vol. 48, No. 18, 2009, p. 1595-1599.Research output: Contribution to journal › Article
TY - JOUR
T1 - Relationship between serum bilirubin and carotid atherosclerosis in hypertensive patients
AU - Yang, Xia-Feng
AU - Chen, Yuan-Zhi
AU - Su, Jiang-Li
AU - Wang, Feng-Yun
AU - Wang, Lexin
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Archives of Internal Medicine. ISSNs: 0003-9926;
PY - 2009
Y1 - 2009
N2 - Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3%) and myocardial infarction (13.5%) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2% and 6.2% respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95% CI, 0.28 to 0.71; P<0.01) and 0.66 (95% CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95% CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95% CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.
AB - Objective: To investigate the relations between serum bilirubin and carotid atherosclerosis in patients with hypertension.Patients and Methods: Carotid artery ultrasonography was performed in 198 patients (104 males, average age of 65.6±7.1 years) with hypertension. Serum levels of bilirubin and C-reactive proteins (CRP) were measured at the same time.Results: Carotid atherosclerosis was detected in 133 patients, 87 of them had carotid artery plaque. The prevalence of stroke (20.3%) and myocardial infarction (13.5%) in the atherosclerosis group was higher than in the non-atherosclerosis group (9.2% and 6.2% respectively, P<0.05). The average total serum bilirubin in the atherosclerosis group was lower than in the non-atherosclerosis group (12.8±1.3 vs 16.8±1.5 'mol/L, P<0.01), whereas the average serum of CRP was higher (4.1±1.1 vs 2.3±0.7 mg/L, P<0.01). After adjusting other factors such as age, total cholesterol, diabetes and systolic blood pressure, total serum bilirubin was negatively associated with carotid atherosclerosis in women and men, with odds ratios of 0.49 (95% CI, 0.28 to 0.71; P<0.01) and 0.66 (95% CI, 0.46 to 0.80; P<0.01). Serum CRP was positively correlated to carotid atherosclerosis, with odds ratios of 1.76 (95% CI, 1.36 to 2.04; P<0.01) in women and 1.95 (95% CI, 1.46 to 2.82; P<0.01) in men.Conclusions: Carotid atherosclerosis is associated with a high prevalence of stroke or myocardial infarction in hypertensive patients. Serum bilirubin is negatively associated with the carotid atherosclerosis.
KW - Atherosclerosis
KW - Bilirubin
KW - C-reactive protein
KW - Carotid plaque
KW - Hypertension
U2 - 10.2169/internalmedicine.48.2286
DO - 10.2169/internalmedicine.48.2286
M3 - Article
VL - 48
SP - 1595
EP - 1599
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 18
ER -