Reply to comments on "highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity"

Richard K. Haynes

doi:10.1002/anie.200462723

Reply to comments on "highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity"

Richard K. Haynes

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

In light of the discussion on C10-substituted derivatives of the antimalarial agent artemisinin in the preceding correspondence article which relates to his earlier work, R. K. Haynes reiterates here that there is no correlation between the ability of artemisinins to react with heme- or non-heme-Fe^II and their antimalarial activity.

Original language	English
Pages (from-to)	2064-2065
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	14
DOIs	https://doi.org/10.1002/anie.200462723
Publication status	Published - 29 Mar 2005

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10.1002/anie.200462723

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title = "Reply to comments on {"}highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity{"}",

abstract = "In light of the discussion on C10-substituted derivatives of the antimalarial agent artemisinin in the preceding correspondence article which relates to his earlier work, R. K. Haynes reiterates here that there is no correlation between the ability of artemisinins to react with heme- or non-heme-FeII and their antimalarial activity.",

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T1 - Reply to comments on "highly antimalaria-active artemisinin derivatives

T2 - Biological activity does not correlate with chemical reactivity"

AU - Haynes, Richard K.

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N2 - In light of the discussion on C10-substituted derivatives of the antimalarial agent artemisinin in the preceding correspondence article which relates to his earlier work, R. K. Haynes reiterates here that there is no correlation between the ability of artemisinins to react with heme- or non-heme-FeII and their antimalarial activity.

AB - In light of the discussion on C10-substituted derivatives of the antimalarial agent artemisinin in the preceding correspondence article which relates to his earlier work, R. K. Haynes reiterates here that there is no correlation between the ability of artemisinins to react with heme- or non-heme-FeII and their antimalarial activity.

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KW - Antiviral agents

KW - Heme proteins

KW - Iron porphyrinoids

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DO - 10.1002/anie.200462723

M3 - Review article

AN - SCOPUS:17044427198

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JF - Angewandte Chemie - International Edition

IS - 14

ER -

Reply to comments on "highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity"

Abstract

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