Repurposing Anakinra for Alzheimer's disease: The in vitro and in vivo effects of Anakinra on LPS- and AC-induced Neuroinflammation.

Keyphrases

• Alzheimer's Disease 100%
• Neuroinflammation 100%
• Lipopolysaccharide 100%
• In Vivo Effects 100%
• Repurposing 100%
• Anakinra 100%
• Acrylamide 42%
• Tumor Necrosis Factor-α 28%
• Anti-neuroinflammation 28%
• Zebrafish Larvae 28%
• Gene Expression 14%
• Induced Activation 14%
• Nitric Oxide 14%
• Expression Level 14%
• Induced Production 14%
• Concentration-dependent 14%
• Interleukin-1β 14%
• In Vitro Study 14%
• Reactive Oxygen Species 14%
• Lipopolysaccharide-induced 14%
• Global Health Issue 14%
• Health Studies 14%
• Antioxidative Effect 14%
• Brain-derived Neurotrophic Factor 14%
• CAMP Response Element-binding Protein 14%
• Swimming Behavior 14%
• Nuclear Transcription Factor 14%
• Neurotrophic Factor Expression 14%
• Nitric Oxide Synthase 2 14%
• BV2 Microglia 14%
• Transcription Factor B 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Repurposing 100%
• Nervous System Inflammation 100%
• Lipopolysaccharide 100%
• Alzheimer's Disease 100%
• Anakinra 100%
• Acrylamide 42%
• Zebra Fish 28%
• Tumor Necrosis Factor 28%
• Binding Protein 14%
• Reactive Oxygen Metabolite 14%
• Interleukin 1 14%
• Brain Derived Neurotrophic Factor 14%
• Alternative Complement Pathway C3 C5 Convertase 14%
• Disease 14%
• Antioxidant 14%
• Transcription Factors 14%
• Nitric Oxide 14%
• Inducible Nitric Oxide Synthase 14%
• Neurotrophic Factor Expression 14%