Resveratrol promotes hypertrophy in wildtype skeletal muscle and reduces muscle necrosis and gene expression of inflammatory markers in Mdx mice

Keryn G. Woodman, Chantal A. Coles, Shireen R. Lamandé, Jason D. White

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Duchenne muscular dystrophy (DMD) is a progressive fatal neuromuscular disorder with no cure. Therapies to restore dystrophin deficiency have been approved in some jurisdictions but long-term effectiveness is yet to be established. There is a need to develop alternative strategies to treat DMD. Resveratrol is a nutraceutical with anti-inflammatory properties. Previous studies have shown high doses (100–400 mg/kg bodyweight/day) benefit mdx mice. We treated 4-week-old mdx and wild type mice with a lower dose of resveratrol (5 mg/kg bodyweight/day) for 15 weeks.Voluntary exercise was used to test if a lower dosage than previously tested could reduce exercise-induced damage where a greater inflammatory infiltrate is present. We found resveratrol promoted skeletal muscle hypertrophy in wild type mice. In dystrophic muscle, resveratrol reduced exercise-induced muscle necrosis. Gene expression of immune cell markers, CD86 and CD163 were reduced;however, signalling targets associated with resveratrol’s mechanism of action including Sirt1 andNF-κB were unchanged. In conclusion, a lower dose of resveratrol compared to the dosage used by other studies reduced necrosis and gene expression of inflammatory cell markers in dystrophic muscle suggesting it as a therapeutic candidate for treating DMD.
    Original languageEnglish
    Article number853
    Number of pages14
    JournalMolecules
    Volume26
    DOIs
    Publication statusPublished - 06 Feb 2021

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