Rhodococcus equi (Prescottella equi) vaccines; the future of vaccine development.

C Giles, Thirumahal Vanniasinkam, S Ndi, M D Barton

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

For decades researchers have been targeting prevention of Rhodococcus equi (Prescottella equi) by vaccination and the horse breeding industry has supported the ongoing efforts by researchers to develop a safe and cost effective vaccine to prevent disease in foals. Traditional vaccines including live, killed and attenuated (physical and chemical) vaccines have proved to be ineffective and more modern molecular-based vaccines including the DNA plasmid, genetically attenuated and subunit vaccines have provided inadequate protection of foals. Newer, bacterial vector vaccines have recently shown promise for R.equi in the mouse model. This article describes the findings of key research in R.equi vaccine development and looks at alternative methods that may potentially be utilised.
Original languageEnglish
Pages (from-to)510-518
Number of pages9
JournalEquine Veterinary Journal
Volume47
Issue number5
Early online dateSep 2014
DOIs
Publication statusPublished - 2015

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