Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka

Lalantha Senevirathna; Tilak Abeysekera; Shanika Nanayakkara; Rohana Chandrajith; Neelakanthi Ratnatunga; Kouji H Harada; Toshiaki Hitomi; Toshiyuki Komiya; Eri Muso; Akio Koizumi

doi:10.1007/s12199-011-0237-7

Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka

Lalantha Senevirathna, Tilak Abeysekera, Shanika Nanayakkara, Rohana Chandrajith, Neelakanthi Ratnatunga, Kouji H Harada, Toshiaki Hitomi, Toshiyuki Komiya, Eri Muso, Akio Koizumi

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Background
The alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.
Methods
This study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.
Results
We repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.
Conclusions
Compared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.

Original language	English
Pages (from-to)	191-198
Number of pages	8
Journal	Environmental Health and Preventive Medicine
Volume	17
Issue number	3
Early online date	2011
DOIs	https://doi.org/10.1007/s12199-011-0237-7
Publication status	Published - 2012

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Senevirathna, L., Abeysekera, T., Nanayakkara, S., Chandrajith, R., Ratnatunga, N., Harada, K. H., Hitomi, T., Komiya, T., Muso, E., & Koizumi, A. (2012). Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka. Environmental Health and Preventive Medicine, 17(3), 191-198. https://doi.org/10.1007/s12199-011-0237-7

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title = "Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka",

abstract = "BackgroundThe alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.MethodsThis study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.ResultsWe repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.ConclusionsCompared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.",

keywords = "Chronic kidney disease of uncertain etiology, Progression, Hyptertension, Sri Lanka",

author = "Lalantha Senevirathna and Tilak Abeysekera and Shanika Nanayakkara and Rohana Chandrajith and Neelakanthi Ratnatunga and Harada, {Kouji H} and Toshiaki Hitomi and Toshiyuki Komiya and Eri Muso and Akio Koizumi",

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Senevirathna, L, Abeysekera, T, Nanayakkara, S, Chandrajith, R, Ratnatunga, N, Harada, KH, Hitomi, T, Komiya, T, Muso, E & Koizumi, A 2012, 'Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka', Environmental Health and Preventive Medicine, vol. 17, no. 3, pp. 191-198. https://doi.org/10.1007/s12199-011-0237-7

Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka. / Senevirathna, Lalantha; Abeysekera, Tilak; Nanayakkara, Shanika et al.
In: Environmental Health and Preventive Medicine, Vol. 17, No. 3, 2012, p. 191-198.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology

T2 - A cohort study in Medawachchiya, Sri Lanka

AU - Senevirathna, Lalantha

AU - Abeysekera, Tilak

AU - Nanayakkara, Shanika

AU - Chandrajith, Rohana

AU - Ratnatunga, Neelakanthi

AU - Harada, Kouji H

AU - Hitomi, Toshiaki

AU - Komiya, Toshiyuki

AU - Muso, Eri

AU - Koizumi, Akio

N1 - Includes bibliographical references

PY - 2012

Y1 - 2012

N2 - BackgroundThe alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.MethodsThis study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.ResultsWe repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.ConclusionsCompared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.

AB - BackgroundThe alarming rise in the prevalence of chronic kidney disease of uncertain etiology (CKDu) among the low socioeconomic farming community in the North Central Province of Sri Lanka has been recognized as an emerging public health issue in the country.MethodsThis study sought to determine the possible factors associated with the progression and mortality of CKDu. The study utilized a single-center cohort registered in 2003 and followed up until 2009 in a regional clinic in the endemic region, and used a Cox proportional hazards model.ResultsWe repeatedly found an association between disease progression and hypertension. Men were at higher risk of CKDu than women. A significant proportion of the patients in this cohort were underweight, which emphasized the need for future studies on the nutritional status of these patients.ConclusionsCompared with findings in western countries and other regions of Asia, we identified hypertension as a major risk factor for progression of CKDu in this cohort.

KW - Chronic kidney disease of uncertain etiology

KW - Progression

KW - Hyptertension

KW - Sri Lanka

U2 - 10.1007/s12199-011-0237-7

DO - 10.1007/s12199-011-0237-7

M3 - Article

SN - 1342-078X

VL - 17

SP - 191

EP - 198

JO - Environmental Health and Preventive Medicine

JF - Environmental Health and Preventive Medicine

IS - 3

ER -

Risk factors associated with disease progression and mortality in chronic kidney disease of uncertain etiology: A cohort study in Medawachchiya, Sri Lanka

Abstract

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