Objective To investigate the predicting factors for persistent atrial fibrillation (AF) following radioiodinetherapy for hyperthyroidism.Methods Standard 12-lead ECG and 24-h Holter monitoring were performed in 94 patients (38 males,mean age 46.1±8.2 years) with persistent AF following radioiodine therapy for hyperthyroidism. Left ventricular(LV) function was assessed with two-dimensional echocardiography.Results Euthyroidism or hypothyroidism was achieved in 81% and 19% of the patients, respectively, afterradioiodine therapy. At the end of follow-up (1.6±1.3 years), LV ejection fraction in the 52 patients with LVdysfunction was increased from 39.3±3.3% to 59.0±5.5% (p<0.01). In the 38 patients with pre-treatment paroxysmalAF, no AF was documented during the follow-up. In the 45 patients with pre-treatment persistentAF, AF was found in 27 (60%) during the follow-up. Multivariate logistic regression analysis showed thatmore than 55 years old in age (RR 2.76, 95% CI: 1.16-8.79, p<0.01), duration of hyperthyroidism (RR 3.08,95% CI: 1.22-11.41, p<0.01) and duration of pre-treatment atrial fibrillation (RR 2.96, 95% CI: 1.31-7.68, p<0.01) were independent predictors for persistent AF following radioiodine therapy.Conclusion Older age, duration of hyperthyroidism and pre-treatment duration of AF are risk factors forpersistent AF following radioiodine therapy.
|Number of pages||5|
|Publication status||Published - 2011|