Role of ACOT7 in Arachidonic Acid Production and Inflammation

Crystall Swarbrick, Jade Forwood, Noelia Roman

Research output: Book chapter/Published conference paperChapter

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Abstract

Acyl-CoA Thioesterases (ACOTs) perform a wide range of cellular functions by catalysingthe thiolytic cleavage of activated fatty acyl-CoAs. Substrates of ACOTs include short tolong-chain acyl-CoAs as well as a range of methyl-branched, and dicarboxylic bile acid-CoAs (M. C. Hunt & Alexson, 2008). Expression of ACOTs have been detected in bothprokaryotes and eukaryotes with expression in higher organisms being detected in cytosol,mitochondria, peroxisomes and endoplasmic reticulum (J. Yamada, 2005).Within the ACOT enzyme family, one member in particular, ACOT7 has recently beenidentified as playing a role inflammation through the production of arachidonic acid (AA).It was recently proposed that ACOT7-mediated AA production may provide acomplementary source of AA to the well characterised phospholipase A2 (PLA2) pathway(Satoru Sakuma, Usa, & Fujimoto, 2006); see Table 1 for review of Acot substrate specificity.Evidence for these observations was through experimental data showing that ACOT7possessed high substrate specificity for AA-CoA; the gene encoding ACOT7 was highlyexpressed in macrophages and up-regulated when stimulated by lipopolysaccharide (LPS);and that over-expression of the enzyme lead to an increase in prostaglandin production.Together, these observations highlight a novel role of ACOT7 in inflammation through theproduction of arachidonic acid from the thiolytic cleavage of activated polyunsaturatedomega-6 fatty acid C20:4-CoA (Forwood et al., 2007).
Original languageEnglish
Title of host publicationInflammatory Diseases
Subtitle of host publicationA Modern Perspective
EditorsAmit Nagal
PublisherInTech
Pages203-218
Number of pages16
Edition10
ISBN (Print)9789533074443
Publication statusPublished - 2011

Fingerprint

Acyl Coenzyme A
Arachidonic Acid
Inflammation
Coenzyme A
Substrate Specificity
Dicarboxylic Acids
Peroxisomes
Phospholipases A2
Enzymes
Eukaryota
Bile Acids and Salts
Endoplasmic Reticulum
Cytosol
Prostaglandins
Lipopolysaccharides
Mitochondria
Fatty Acids
Macrophages
Genes

Cite this

Swarbrick, C., Forwood, J., & Roman, N. (2011). Role of ACOT7 in Arachidonic Acid Production and Inflammation. In A. Nagal (Ed.), Inflammatory Diseases: A Modern Perspective (10 ed., pp. 203-218). InTech.
Swarbrick, Crystall ; Forwood, Jade ; Roman, Noelia. / Role of ACOT7 in Arachidonic Acid Production and Inflammation. Inflammatory Diseases: A Modern Perspective. editor / Amit Nagal. 10. ed. InTech, 2011. pp. 203-218
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Swarbrick, C, Forwood, J & Roman, N 2011, Role of ACOT7 in Arachidonic Acid Production and Inflammation. in A Nagal (ed.), Inflammatory Diseases: A Modern Perspective. 10 edn, InTech, pp. 203-218.

Role of ACOT7 in Arachidonic Acid Production and Inflammation. / Swarbrick, Crystall; Forwood, Jade; Roman, Noelia.

Inflammatory Diseases: A Modern Perspective. ed. / Amit Nagal. 10. ed. InTech, 2011. p. 203-218.

Research output: Book chapter/Published conference paperChapter

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AU - Swarbrick, Crystall

AU - Forwood, Jade

AU - Roman, Noelia

N1 - Imported on 12 May 2017 - DigiTool details were: publisher = Intech, 2011. editor/s (773b) = Amit Nagal; Issue no. (773s) = 10; Parent title (773t) = Inflammatory Diseases - A Modern Perspective.

PY - 2011

Y1 - 2011

N2 - Acyl-CoA Thioesterases (ACOTs) perform a wide range of cellular functions by catalysingthe thiolytic cleavage of activated fatty acyl-CoAs. Substrates of ACOTs include short tolong-chain acyl-CoAs as well as a range of methyl-branched, and dicarboxylic bile acid-CoAs (M. C. Hunt & Alexson, 2008). Expression of ACOTs have been detected in bothprokaryotes and eukaryotes with expression in higher organisms being detected in cytosol,mitochondria, peroxisomes and endoplasmic reticulum (J. Yamada, 2005).Within the ACOT enzyme family, one member in particular, ACOT7 has recently beenidentified as playing a role inflammation through the production of arachidonic acid (AA).It was recently proposed that ACOT7-mediated AA production may provide acomplementary source of AA to the well characterised phospholipase A2 (PLA2) pathway(Satoru Sakuma, Usa, & Fujimoto, 2006); see Table 1 for review of Acot substrate specificity.Evidence for these observations was through experimental data showing that ACOT7possessed high substrate specificity for AA-CoA; the gene encoding ACOT7 was highlyexpressed in macrophages and up-regulated when stimulated by lipopolysaccharide (LPS);and that over-expression of the enzyme lead to an increase in prostaglandin production.Together, these observations highlight a novel role of ACOT7 in inflammation through theproduction of arachidonic acid from the thiolytic cleavage of activated polyunsaturatedomega-6 fatty acid C20:4-CoA (Forwood et al., 2007).

AB - Acyl-CoA Thioesterases (ACOTs) perform a wide range of cellular functions by catalysingthe thiolytic cleavage of activated fatty acyl-CoAs. Substrates of ACOTs include short tolong-chain acyl-CoAs as well as a range of methyl-branched, and dicarboxylic bile acid-CoAs (M. C. Hunt & Alexson, 2008). Expression of ACOTs have been detected in bothprokaryotes and eukaryotes with expression in higher organisms being detected in cytosol,mitochondria, peroxisomes and endoplasmic reticulum (J. Yamada, 2005).Within the ACOT enzyme family, one member in particular, ACOT7 has recently beenidentified as playing a role inflammation through the production of arachidonic acid (AA).It was recently proposed that ACOT7-mediated AA production may provide acomplementary source of AA to the well characterised phospholipase A2 (PLA2) pathway(Satoru Sakuma, Usa, & Fujimoto, 2006); see Table 1 for review of Acot substrate specificity.Evidence for these observations was through experimental data showing that ACOT7possessed high substrate specificity for AA-CoA; the gene encoding ACOT7 was highlyexpressed in macrophages and up-regulated when stimulated by lipopolysaccharide (LPS);and that over-expression of the enzyme lead to an increase in prostaglandin production.Together, these observations highlight a novel role of ACOT7 in inflammation through theproduction of arachidonic acid from the thiolytic cleavage of activated polyunsaturatedomega-6 fatty acid C20:4-CoA (Forwood et al., 2007).

KW - Open access version available

M3 - Chapter

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EP - 218

BT - Inflammatory Diseases

A2 - Nagal, Amit

PB - InTech

ER -

Swarbrick C, Forwood J, Roman N. Role of ACOT7 in Arachidonic Acid Production and Inflammation. In Nagal A, editor, Inflammatory Diseases: A Modern Perspective. 10 ed. InTech. 2011. p. 203-218