Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries

Sokcheon Pak; Sung Chul Lim; Seung-Yeol Nah; Jiae Lee; Joseph A. Hill; Chun Sik Bae

doi:10.1016/j.fertnstert.2005.04.042

Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries

Sokcheon Pak, Sung Chul Lim, Seung-Yeol Nah, Jiae Lee, Joseph A. Hill, Chun Sik Bae

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19 Citations (Scopus)

Abstract

Objective To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus. Design Polycystic ovary (PCO) rat model induced by estradiol valerate (EV). Setting University research laboratory. Patient(s) Thirty sexually mature female Sprague-Dawley rats weighing 190'210 g. Intervention(s) Female Sprague-Dawley rats (190'210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10). Main Outcome Measure(s) Ovarian morphology and NGF protein expression. Result(s) Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain. Conclusion(s) Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.

Original language	English
Pages (from-to)	1139-1143
Number of pages	5
Journal	Fertility and Sterility
Volume	84
Issue number	Supplement 2
DOIs	https://doi.org/10.1016/j.fertnstert.2005.04.042
Publication status	Published - 2005

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10.1016/j.fertnstert.2005.04.042

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@article{3cb5defec8a348c3be40a2f3b832b217,

title = "Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries",

abstract = "Objective To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus. Design Polycystic ovary (PCO) rat model induced by estradiol valerate (EV). Setting University research laboratory. Patient(s) Thirty sexually mature female Sprague-Dawley rats weighing 190'210 g. Intervention(s) Female Sprague-Dawley rats (190'210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10). Main Outcome Measure(s) Ovarian morphology and NGF protein expression. Result(s) Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain. Conclusion(s) Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.",

author = "Sokcheon Pak and Lim, {Sung Chul} and Seung-Yeol Nah and Jiae Lee and Hill, {Joseph A.} and Bae, {Chun Sik}",

note = "Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Fertility and Sterility. ISSNs: 0015-0282; ",

year = "2005",

doi = "10.1016/j.fertnstert.2005.04.042",

language = "English",

volume = "84",

pages = "1139--1143",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "Supplement 2",

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TY - JOUR

T1 - Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries

AU - Pak, Sokcheon

AU - Lim, Sung Chul

AU - Nah, Seung-Yeol

AU - Lee, Jiae

AU - Hill, Joseph A.

AU - Bae, Chun Sik

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Fertility and Sterility. ISSNs: 0015-0282;

PY - 2005

Y1 - 2005

N2 - Objective To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus. Design Polycystic ovary (PCO) rat model induced by estradiol valerate (EV). Setting University research laboratory. Patient(s) Thirty sexually mature female Sprague-Dawley rats weighing 190'210 g. Intervention(s) Female Sprague-Dawley rats (190'210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10). Main Outcome Measure(s) Ovarian morphology and NGF protein expression. Result(s) Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain. Conclusion(s) Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.

AB - Objective To investigate the effect of Korean red ginseng total saponins (GTS) on ovarian morphology and nerve growth factor (NGF) expression in the ovaries, pituitary, and hippocampus. Design Polycystic ovary (PCO) rat model induced by estradiol valerate (EV). Setting University research laboratory. Patient(s) Thirty sexually mature female Sprague-Dawley rats weighing 190'210 g. Intervention(s) Female Sprague-Dawley rats (190'210 g) were separated into three groups: EV control (n = 10), EV plus GTS (n = 10), and oil control (n = 10). Main Outcome Measure(s) Ovarian morphology and NGF protein expression. Result(s) Polycystic ovary was fully developed in rats with a single intramuscular injection of EV. Increased expression of NGF was noted in the ovaries and the brain of rats with PCO. GTS administration attenuated NGF expression in the ovaries but not in the brain. Conclusion(s) Our findings suggest a role for GTS in the regulation of NGF expression in female rats with PCO.

U2 - 10.1016/j.fertnstert.2005.04.042

DO - 10.1016/j.fertnstert.2005.04.042

M3 - Article

SN - 0015-0282

VL - 84

SP - 1139

EP - 1143

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - Supplement 2

ER -

Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries

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