Rosai-Dorfman disease of thesubdural spine with a longsegment lesion: A case report and literature review

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy is a rarebenign disorder usually characterized by massive painless cervical lymphadenopathy and systemicmanifestations. Extranodal involvement, especially spinal involvement, is extremely rare.We report a 41-year-old man who presented with only intermittent dorsodynia. His conditionwas diagnosed as non-specific inflammatory disease on the basis of preoperative puncture biopsyresults. We performed total surgical resection. Histopathological findings showed distinctiveemperipolesis and immunohistochemistry results were positive for cluster of differentiation CD68and S100 and negative for CD1a. A good prognosis was confirmed at the 3-month follow-up visit.This is the first case of RDD of the subdural spine with such a long segment lesion. There is still noconsensus regarding appropriate therapy for this type of RDD and the preoperative diagnosisremains challenging. The unusual presentation of our case serves as a reference when diagnosingand treating RDD.