Rotavirus vaccine trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and future use of the vaccine in Bangladesh

K. Zaman, Asma Binte Aziz, Md Yunus, Firdausi Qadri, Allen G. Ross, John D. Clemens

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Abstract

Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) has completed several groundbreaking RV trials (Phase I-Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh.
Original languageEnglish
Pages (from-to)S801-S804
Number of pages4
JournalJournal of Infectious Diseases
Volume224
Issue numberS7
DOIs
Publication statusPublished - 15 Dec 2021

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