Schistosomiasis in the People's Republic of China: Prospects and challenges for the 21st century

A. G.P. Ross, A. C. Sleigh, Y. Li, G. M. Davis, G. M. Williams, Z. Jiang, Z. Feng, D. P. McManus

    Research output: Contribution to journalArticlepeer-review

    282 Citations (Scopus)

    Abstract

    Schistosomiasis japonica is a serious communicable disease and a major disease risk more than 30 million people living in the tropical and subtropical zones of China. Infection remains a major public health concern despite 45 years of intensive control efforts. It is estimated that 865,000 people and 100,250 bovines are today infected in the provinces where the disease is endemic, and its transmission continues, Unlike the other schistosome species known to infect humans, the oriental schistosome, Schistosome japonicum, is a true zoonotic organism, with a range of mammalian reservoirs, making control efforts extremely difficult. Clinical features of schistosomiasis range from fever, headache, and lethargy to severe fibro-obstructive pathology leading to portal hypertension, ascites, and hepatosplenomegaly, which can cause premature death, Infected children are stunted and have cognitive defects impairing memory and learning ability, Current control programs are heavily based n community chemotherapy with a single dose of the drug praziquantel, but vaccines (for use in bovines and humans) in combination with other control strategies and needed to make elimination of the disease possible. In this article, we provide an overview of the biology, epidemiology, clinical features, and prospects for control of oriental schistosomiasis in the People's Republic of China.

    Original languageEnglish
    Pages (from-to)270-295
    Number of pages26
    JournalClinical Microbiology Reviews
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2001

    Fingerprint

    Dive into the research topics of 'Schistosomiasis in the People's Republic of China: Prospects and challenges for the 21st century'. Together they form a unique fingerprint.

    Cite this