Selective targeting of protein kinase C (PKC)-θ nuclear translocation reduces mesenchymal gene signatures and reinvigorates dysfunctional CD8+ T cells in immunotherapy-resistant and metastatic cancers

Jenny Dunn, Robert D. McCuaig, Abel H.Y. Tan, Wen Juan Tu, Fan Wu, Kylie M. Wagstaff, Anjum Zafar, Sayed Ali, Himanshu Diwakar, Jane E. Dahlstrom, Elaine G. Bean, Jade K. Forwood, Sofiya Tsimbalyuk, Emily M. Cross, Kristine Hardy, Amanda L. Bain, Elizabeth Ahern, Riccardo Dolcetti, Roberta Mazzieri, Desmond YipMelissa Eastgate, Laeeq Malik, Peter Milburn, David A. Jans, Sudha Rao

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Immunology and Microbiology