Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention

X-J Zhang, T-W Sun, Q-C Kan, H-M Yao, Y-D Wan, R Yao, F-X Guan, C-Q Guo, S-G Zhang, W-J Sun, Lexin Wang

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Abstract

Purpose: The purpose of this study was to investigate the associated between serum total bilirubin (STB) levels and long-term outcomes in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods: A total of 1,273 consecutive patients were enrolled. Patients were grouped according to their baseline STB levels: Group 1 (STB < 3.4 µmol/L), Group 2 (3.4 µmol/L = STB = 10.3 µmol/L), Group 3 (10.3 µmol/L < STB = 17.1 µmol/L), and Group 4 (STB > 17.1 µmol/L) and the rate of major adverse cardiovascular events (MACE) was determined. Results: A total of 1,152 patients were successfully followed up (90.5%) for a mean period of 30 ± 5 months, including 187 patients experiencing a major adverse cardiovascular event (MACE: death from any cause, myocardial infarction, repeat revascularization or readmission). The MACE rate in Groups 3 and 4 was lower than in Groups 1 and 2 (P < 0.01). After adjusted the confounding factors with Cox regression analysis, the MACE rates in Groups 2-4 were still lower than in Group 1 (Group 2, RR=0.293, 95% CI 0.167-0.517, P<0.01; Group 3, RR=0.142, 95% CI 0.065-0.312, P<0.01; Group 4, RR=0.134, 95% CI 0.071-0.252, P<0.01). The cumulative survival rates of Groups 3 and 4 were higher than that of Groups 1and 2 (P<0.01). Conclusions: High STB concentration is associated with lower MACE in patients with ACS after PCI. [ABSTRACT FROM AUTHOR]
Original languageEnglish
Pages (from-to)E345-E351
Number of pages7
JournalClinical and Investigative Medicine
Volume37
Issue number5
DOIs
Publication statusPublished - Oct 2014

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    Zhang, X-J., Sun, T-W., Kan, Q-C., Yao, H-M., Wan, Y-D., Yao, R., Guan, F-X., Guo, C-Q., Zhang, S-G., Sun, W-J., & Wang, L. (2014). Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention. Clinical and Investigative Medicine, 37(5), E345-E351. https://doi.org/10.25011/cim.v37i5.22015