Simulated maximum likelihood method for estimating kinetic rates in gene expression

Tianhai Tian, Songlin Xu, Junbin Gao, Kevin Burrage

    Research output: Contribution to journalArticlepeer-review

    75 Citations (Scopus)


    Kinetic rate in gene expression is a key measurement of the stability of gene products and gives important information for the reconstruction of genetic regulatory networks. Recent developments in experimental technologies have made it possible to measure the numbers of transcripts and protein molecules in single cells. Although estimation methods based on deterministic models have been proposed aimed at evaluating kinetic rates from experimental observations, these methods cannot tackle noise in gene expression that may arise from discrete processes of gene expression, small numbers of mRNA transcript, fluctuations in the activity of transcriptional factors and variability in the experimental environment.
    Original languageEnglish
    Pages (from-to)84-91
    Number of pages8
    Issue number1
    Publication statusPublished - 2007


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