Abstract
Subclinical mastitis and Johne’s disease due to infection with
MAP are two inflammatory diseases that have distinct
economic impacts on dairy producers. Both of these chronic
diseases have been associated with an inherent dysregulation of
the immune system, altering the balance between type-1 (proinflammatory)
and type-2 (anti-inflammatory) immune responses.
We hypothesize that genetic variation can influence
the host’s ability to regulate its immune response during
infection, potentially leading to a chronic pathological state
in which the likelihood of eliminating the pathogen is greatly
reduced. To investigate this we identified SNPs in genes coding
two prominent anti-inflammatory cytokines, IL-10 (2 SNPs)
and TGF-b (1 SNPs), and the receptor subunits, IL10Ra (7
SNPs), IL10Rb (2 SNPs), and tested their association to the
incidence of sub-clinical Johne’s disease and estimated breeding
values for milk somatic cell score (SCS) in a population of
more than 300 dairy cows and 600 dairy bulls, respectively.
Significant associations were found in both cases, suggesting
that variants in these genes may contribute to host susceptibility
to mastitis or Johne’s disease.
MAP are two inflammatory diseases that have distinct
economic impacts on dairy producers. Both of these chronic
diseases have been associated with an inherent dysregulation of
the immune system, altering the balance between type-1 (proinflammatory)
and type-2 (anti-inflammatory) immune responses.
We hypothesize that genetic variation can influence
the host’s ability to regulate its immune response during
infection, potentially leading to a chronic pathological state
in which the likelihood of eliminating the pathogen is greatly
reduced. To investigate this we identified SNPs in genes coding
two prominent anti-inflammatory cytokines, IL-10 (2 SNPs)
and TGF-b (1 SNPs), and the receptor subunits, IL10Ra (7
SNPs), IL10Rb (2 SNPs), and tested their association to the
incidence of sub-clinical Johne’s disease and estimated breeding
values for milk somatic cell score (SCS) in a population of
more than 300 dairy cows and 600 dairy bulls, respectively.
Significant associations were found in both cases, suggesting
that variants in these genes may contribute to host susceptibility
to mastitis or Johne’s disease.
| Original language | English |
|---|---|
| Pages | 155-155 |
| Number of pages | 1 |
| Publication status | Published - 2009 |
| Event | Canadian Society of Animal Science Annual Meeting - Montreal, Quebec, Canada Duration: 16 Mar 2008 → 18 Mar 2008 |
Conference
| Conference | Canadian Society of Animal Science Annual Meeting |
|---|---|
| Country/Territory | Canada |
| City | Montreal, Quebec |
| Period | 16/03/08 → 18/03/08 |