TY - JOUR
T1 - Some European Gentiana species are used traditionally to cure wounds
T2 - Bioactivity and conservation issues
AU - Pasdaran, Ardalan
AU - Naychov, Zheko
AU - Batovska, Daniela
AU - Kerr, Philip
AU - Favre, Adrien
AU - Dimitrov, Vladimir
AU - Aneva, Ina
AU - Hamedi, Azadeh
AU - Kozuharova, Ekaterina
N1 - Funding Information:
This study was conducted with the help of the project “Conservation of European Biodiversity through Exploitation of Traditional Herbal Knowledge for the Development of Innovative Products”, Horizon 2020, H2020-MSCA-RISE-2018, Proposal number: 823973, and Proposal acronym: EthnoHERBS.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - Wound care will always be among the main tasks in
all surgical specialties. Several medicinal plants have proven efficacy
to cure wounds. Ethnobotanical research and ethnopharmacological
research have virtually endless potential to find new lead compounds.
The aim of this research review is to assess the potential of some Gentiana
species as sources of promising active compounds to support wound
healing. Gentians are among the most popular medicinal plants used in
many countries for a wide spectrum of health conditions. Traditionally,
those used to cure wounds are Gentiana lutea, G. punctata, G. asclepiadea, G. cruciata, G. oliverii, G. septemphida, and G. gelida.
Candidate compounds with skin regeneration and wound-healing potential
isolated from gentians are isogentisin, isoorientin, mangiferin, lupeol,
pinoresinol, syringaresinol, eustomoside, and sweroside. Based on the
rich source of traditional knowledge on the properties of gentians to
cure various skin and soft tissue complications; only very few modern
pharmacological studies have been performed to test this potential. Our
review demonstrates that this field deserves further investigation. Many
gentians are declining in number and have high IUCN conservation
status, and cultivation and micropropagation methods are the only
solution for the development of new drugs based on gentian extracts.
AB - Wound care will always be among the main tasks in
all surgical specialties. Several medicinal plants have proven efficacy
to cure wounds. Ethnobotanical research and ethnopharmacological
research have virtually endless potential to find new lead compounds.
The aim of this research review is to assess the potential of some Gentiana
species as sources of promising active compounds to support wound
healing. Gentians are among the most popular medicinal plants used in
many countries for a wide spectrum of health conditions. Traditionally,
those used to cure wounds are Gentiana lutea, G. punctata, G. asclepiadea, G. cruciata, G. oliverii, G. septemphida, and G. gelida.
Candidate compounds with skin regeneration and wound-healing potential
isolated from gentians are isogentisin, isoorientin, mangiferin, lupeol,
pinoresinol, syringaresinol, eustomoside, and sweroside. Based on the
rich source of traditional knowledge on the properties of gentians to
cure various skin and soft tissue complications; only very few modern
pharmacological studies have been performed to test this potential. Our
review demonstrates that this field deserves further investigation. Many
gentians are declining in number and have high IUCN conservation
status, and cultivation and micropropagation methods are the only
solution for the development of new drugs based on gentian extracts.
KW - bioactive compounds
KW - biodiversity
KW - ethnobotany
KW - folk medicine
KW - Gentianaceae
KW - wound care
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U2 - 10.3390/d15030467
DO - 10.3390/d15030467
M3 - Review article
AN - SCOPUS:85151701942
SN - 1424-2818
VL - 15
SP - 1
EP - 20
JO - Diversity
JF - Diversity
IS - 3
M1 - 467
ER -