The purpose of this study was to determine if the application of tissue harmonic imaging (THI) and real-time spatial compounding (RTSC) would result in a significant difference in the rate of detection and quality of visualization of the normal appendix. Subjects were scanned using the experimental method (the combination of THI and RTSC) and the conventional method (without THI and RTSC). The rate of detection was 85% with the experimental method and 66% with the conventional method. The quality of visualization was measured across three scales'visualized length, walls, and lumen'with a total score equal to the sum of the three scales. The experimental method demonstrated a significant difference in visualized length and total score. The mean score for length using the conventional method was 2.18 compared with 2.56 for the experimental method. The mean score for all three scales for the conventional method was 7.97 compared with 8.67 for the experimental method.