Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol

Elsa Caytan, Younes Cherghaoui, Celia Barril, Catherine Jouitteau, Claude Rabiller, Gerald S. Remaud

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.
    Original languageEnglish
    Pages (from-to)1622-1624
    Number of pages3
    JournalTetrahedron Asymmetry
    Volume17
    Issue number11
    DOIs
    Publication statusPublished - Jul 2006

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