Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol

Elsa Caytan; Younes Cherghaoui; Celia Barril; Catherine Jouitteau; Claude Rabiller; Gerald S. Remaud

doi:10.1016/j.tetasy.2006.05.031

Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol

Elsa Caytan, Younes Cherghaoui, Celia Barril, Catherine Jouitteau, Claude Rabiller, Gerald S. Remaud

Research output: Contribution to journal › Article › peer-review

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Abstract

The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.

Original language	English
Pages (from-to)	1622-1624
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	17
Issue number	11
DOIs	https://doi.org/10.1016/j.tetasy.2006.05.031
Publication status	Published - Jul 2006

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10.1016/j.tetasy.2006.05.031

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title = "Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol",

abstract = "The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.",

keywords = "Glycerol, SNIF NMR, Site-specific isotope ratio",

author = "Elsa Caytan and Younes Cherghaoui and Celia Barril and Catherine Jouitteau and Claude Rabiller and Remaud, {Gerald S.}",

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doi = "10.1016/j.tetasy.2006.05.031",

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TY - JOUR

T1 - Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules

T2 - application to glycerol

AU - Caytan, Elsa

AU - Cherghaoui, Younes

AU - Barril, Celia

AU - Jouitteau, Catherine

AU - Rabiller, Claude

AU - Remaud, Gerald S.

N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = July 2006; Journal title (773t) = Tetrahedron-Asymmetry. ISSNs: 0957-4166;

PY - 2006/7

Y1 - 2006/7

N2 - The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.

AB - The strategy for the measurement of the site-specific isotope ratios by NMR within a symmetrical molecule is illustrated by the determination of the site-specific 13C content in glycerol on the basis of (i) a selective derivatisation of glycerol, carried out by a lipase (Candida antarctica) to overcome the symmetry of the molecule, (ii) purification of the (R)-monobenzoate glycerol with a high enantiomeric excess and (iii) use of this derivative for quantitative 13C NMR spectroscopy for the determination of 13C isotopomer concentrations.

KW - Glycerol

KW - SNIF NMR

KW - Site-specific isotope ratio

U2 - 10.1016/j.tetasy.2006.05.031

DO - 10.1016/j.tetasy.2006.05.031

M3 - Article

SN - 0957-4166

VL - 17

SP - 1622

EP - 1624

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 11

ER -

Strategy for specific isotope ratio determination by quantitative NMR on symmetrical molecules: application to glycerol

Abstract

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