Structure, function, and regulation of thioesterases

Crystall M.D. Swarbrick, Jeffrey D. Nanson, Edward I. Patterson, Jade K. Forwood

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Thioesterases are present in all living cells and perform a wide range of important biological functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular substrates. Thioesterases are organised into 25 families based on their sequence conservation, tertiary and quaternary structure, active site configuration, and substrate specificity. Recent structural and functional characterisation of thioesterases has led to significant changes in our understanding of the regulatory mechanisms that govern enzyme activity and their respective cellular roles. The resulting dogma changes in thioesterase regulation include mechanistic insights into ATP and GDP-mediated regulation by oligomerisation, the role of new key regulatory regions, and new insights into a conserved quaternary structure within TE4 family members. Here we provide a current and comparative snapshot of our understanding of thioesterase structure, function, and regulation across the different thioesterase families.

Original languageEnglish
Article number101036
Pages (from-to)1-31
Number of pages31
JournalProgress in Lipid Research
Early online date19 May 2020
Publication statusPublished - Jul 2020


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