Studies on the unique properties of resistant starch and chito-oligosaccharide complexes for reducing high-fat diet-induced obesity and dyslipidemia in rats

Wenting Shang, Xu Si, Zhong Kai Zhou, Junxuan Wang, Padraig Strappe, Chris Blanchard

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Anti-obesity effect of chito-oligosaccharides (CO), resistant starch (RS) and their complexes (CO-RS) was investigated using high-fat fed rats. All of three intervention groups showed anti-obesity effect in the following order: CO-RS > CO > RS. This study revealed CO-RS administration achieved the lightest body weight, the lowest liver weight/index and the highest level of total antioxidant capacity in serum. The RNA sequencing data indicated that peroxisome proliferator-activated receptor (PPAR) pathway was significantly enriched by CO-RS administration. Among the genes involved in PPAR pathway, changes in the expression of Cyp7a1 gene were noticed, indicating an accelerated conversion of cholesterol into bile acids. Furthermore, the current study also revealed that, compared to the high-fat diet control, intervention with CO-RS led to significant reduction in mRNA expression of insulin-induced genes (Insig-1), which did not occur in other two interventions, suggesting a different regulatory pathway affecting lipids metabolism compared with either CO or RS.
Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalJournal of Functional Foods
Volume38
Early online date04 Sep 2017
DOIs
Publication statusPublished - Nov 2017

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