Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease

Jianxiong. School of Biomedical Sciences Wang, Shi Zhou, Roger Bronks, John Graham, Stephen Myers

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Objectives: To evaluate whether a combination of supervised exercise training and ginkgo biloba treatment is a better treatment, compared to exercise training alone, for patients with peripheral arterial disease.Design: A 24-week double-blind, placebo-controlled ginkgo biloba trial with the first 12-week period as a non-exercise control stage and the second 12-week period as an exercise training stage.Setting: Exercise physiology laboratory.Subjects: Twenty-two subjects with peripheral arterial disease.Interventions: The subjects were randomly allocated into a ginkgo or a placebo group. During the first stage, the ginkgo group ingested standardised ginkgo biloba tablets with a daily dosage of 240 mg, while the placebo group received placebo tablets. During the second stage, all subjects engaged in a supervised treadmill-walking program while continued taking the same dosage of ginkgo biloba or placebo tablets.Main measures: Walking capacity on treadmill, oxygen consumption during exercise, peripheral hemodynamics and blood viscosity were measured at baseline, and after the first and the second stages of treatment.Results: The ginkgo group did not show significant changes in most of the measured variables after each stage of treatment, except that the maximal walking time was significantly increased after the combined treatment (from 236±112 s to 557±130 s, p<0.001). However, similar response was also found in the placebo group after exercise training (from 384±125 s to 820±146 s, p<0.001).Conclusion: Supervised exercise training combined with ginkgo biloba treatment did not produce greater beneficial effects than exercise training alone in patients with peripheral arterial disease.
Original languageEnglish
Pages (from-to)579-586
Number of pages8
JournalClinical Rehabilitation
Issue number7
Publication statusPublished - 2007


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