TY - JOUR
T1 - Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40
AU - Tomasec, Peter
AU - Braud, Veronique M.
AU - Rickards, Carole
AU - Powell, Martin B.
AU - McSharry, Brian P.
AU - Gadola, Stephan
AU - Cerundolo, Vincenzo
AU - Borysiewicz, Leszek K.
AU - McMichae, Andrew J.
AU - Wilkinson, Gavin W.G.
PY - 2000/2/11
Y1 - 2000/2/11
N2 - The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell-mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived from MHC class I molecules. The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glycoprotein UL40 (gpUL40). It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis. White classical MHC class I molecules are down-regulated, HLA-E is up-regulated by HCMV. Induction of HLA-E surface expression by gpUL40 may represent an escape route for HCMV.
AB - The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell-mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived from MHC class I molecules. The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glycoprotein UL40 (gpUL40). It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis. White classical MHC class I molecules are down-regulated, HLA-E is up-regulated by HCMV. Induction of HLA-E surface expression by gpUL40 may represent an escape route for HCMV.
KW - Amino Acid Sequence
KW - Amino Acid Substitution
KW - Antigens, CD
KW - Cell Line
KW - Cell Membrane/immunology
KW - Cells, Cultured
KW - Conserved Sequence
KW - Cytomegalovirus/genetics
KW - Cytotoxicity, Immunologic
KW - Down-Regulation
KW - HLA Antigens/immunology
KW - Histocompatibility Antigens Class I/immunology
KW - Humans
KW - Killer Cells, Natural/immunology
KW - Leukocyte Immunoglobulin-like Receptor B1
KW - Molecular Sequence Data
KW - Open Reading Frames
KW - Protein Sorting Signals/chemistry
KW - Receptors, Immunologic/metabolism
KW - Recombinant Fusion Proteins/chemistry
KW - Transfection
KW - Up-Regulation
KW - Viral Proteins/chemistry
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UR - http://www.scopus.com/inward/citedby.url?scp=0034635414&partnerID=8YFLogxK
U2 - 10.1126/science.287.5455.1031
DO - 10.1126/science.287.5455.1031
M3 - Article
C2 - 10669413
AN - SCOPUS:0034635414
SN - 0036-8075
VL - 287
SP - 1031
EP - 1033
JO - Science
JF - Science
IS - 5455
ER -