In the wine industry 2,4,6-trichloroanisole (TCA) has been identified as the primary contaminant responsible for 'cork taint'. A molecularly imprinted polymer (MIP) selective for TCA was prepared in three porogens (hexane, acetonitrile, and dichloromethane) of varying polarities using non-covalent molecular imprinting techniques. Target rebinding to the MIP was found to be most effective in its porogenic solvent and highest in dichloromethane (imprinting factor = 3.65). Competitive binding assays performed against a range of close structural analogues demonstrated a preference for the target molecule.
Schwarz, L., Bowyer, M., Dr Clovia, I. H., & McCluskey, A. (2006). Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichloroanisole. Australian Journal of Chemistry, 59, 759-764. https://doi.org/10.1071/CH05318