Synthesis and intramolecular inclusion of beta-cyclodextrins linked with a cyclohexyl group

Dong Bo Li, Siu-Choon Ng, Igor Novak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cyclohexanecarboxylic acid (6A-deoxy-ß-cyclodextrin-6A-C-yl)-amide (CHC-ßCD) was synthesized via an aza-Wittig reaction and found to form in water, a temperature-independent intramolecular complex with its own cyclohexyl moiety. The analysis was based on data from 2D and variable-temperature NMR spectroscopy. The self-inclusion behavior of peracetylated CHC-ßCD (PACHC-ßCD) in chloroform was also investigated.Cyclohexanecarboxylic acid (6A-deoxy-ß-cyclodextrin-6A-C-yl)-amide (CHC-ßCD) was synthesized via an aza-Wittig reaction and found to form in water, a temperature-independent intramolecular complex with its own cyclohexyl moiety. The analysis was based on data from 2D and variable-temperature NMR spectroscopy. The self-inclusion behavior of peracetylated CHC-ßCD (PACHC-ßCD) in chloroform was also investigated.
Original languageEnglish
Pages (from-to)1871-1875
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number10
DOIs
Publication statusPublished - 2002

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