Synthesis of a structurally constrained endoperoxide having antimalarial activity from α-santonin

C. W. Van Der Westhuyzen, C. J. Parkinson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

α-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalSouth African Journal of Chemistry
Volume58
Publication statusPublished - 14 Feb 2005

Fingerprint Dive into the research topics of 'Synthesis of a structurally constrained endoperoxide having antimalarial activity from α-santonin'. Together they form a unique fingerprint.

  • Cite this