Systematic approach to identify therapeutic targets and functional pathways for the cervical cancer

Md Tanvir Hasan, Md Rakibul Islam, Md Rezwan Islam, Baraa Riyadh Altahan, Kawsar Ahmed, Francis M. Bui, Sami Azam, Mohammad Ali Moni

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: In today’s society, cancer has become a big concern. The most common cancers in women are breast cancer (BC), endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC). CC is a type of cervix cancer that is the fourth most common cancer in women and the fourth major cause of death. Results: This research uses a network approach to discover genetic connections, functional enrichment, pathways analysis, microRNAs transcription factors (miRNA-TF) co-regulatory network, gene-disease associations, and therapeutic targets for CC. Three datasets from the NCBI’s GEO collection were considered for this investigation. Then, using a comparison approach between the datasets, 315 common DEGs were discovered. The PPI network was built using a variety of combinatorial statistical approaches and bioinformatics tools, and the PPI network was then utilized to identify hub genes and critical modules. Conclusion: Furthermore, we discovered that CC has specific similar links with the progression of different tumors using Gene Ontology terminology and pathway analysis. Transcription factors-gene linkages, gene-disease correlations, and the miRNA-TF co-regulatory network were revealed to have functional enrichments. We believe the candidate drugs identified in this study could be effective for advanced CC treatment.

Original languageEnglish
Article number10
Number of pages17
JournalJournal of Genetic Engineering and Biotechnology
Volume21
Issue number1
DOIs
Publication statusPublished - Dec 2023

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