High-throughput genotype data have been extensively used to investigate the biological and genetic background of complex traits, such as obesity. However, results explaining complete genetic variation are limited. Systems genetics approaches are increasingly used to elucidate more of the currently limited knowledge of complex traits. Weighted Interaction SNP Hub (WISH) network method is a novel tool which is able to elucidate underlying biology and capture potential causal variants. Here we studied obesity, using systems genetics approaches in an F2 pig population. We created an Obesity Index (OI) based on multi-trait selection indexes containing nine obesity-related phenotypes, to perform a GWAS and WISH network analysis. WISH detected several modules associated with OI. Functional annotation revealed several genes (e.g. NPC2) and pathways (e.g. the insulin signaling pathway) which were (in-)directly related to obesity. This study shows the potential for systems genetics analysis of high-throughput genotype data for obesity.
|Title of host publication||Proceedings, 10th World Congress of Genetics Applied to Livestock Production|
|Number of pages||3|
|Publication status||Published - 2014|
|Event||10th World Congress of Genetics Applied to Livestock Production: WCGALP 2014 - Westin Bayshore Conference Center, Vancouver, Canada|
Duration: 17 Aug 2014 → 22 Aug 2014
https://web.archive.org/web/20140805071635/http://www.wcgalp.com/ (Conference website)
http://www.wcgalp.org/proceedings/2014 (Conference proceedings)
|Conference||10th World Congress of Genetics Applied to Livestock Production|
|Period||17/08/14 → 22/08/14|
|Other||The joint US-Canada organizing committee is proud to welcome you to the 10th World Congress on Genetics Applied to Livestock Production (WCGALP) being held from 17 – 22 August 2014 at the Westin Bayshore Conference Center situated on the bay in the gorgeous city of Vancouver, British Columbia, Canada. |
This congress is the premier conference for researchers and professionals involved in genetic improvement of livestock. Delegates from around the world gather every four years to attend the scientific program and network with colleagues. This 10th WGCALP builds from previous successful congresses in Madrid (1974 and 1982), Lincoln (USA, 1986), Edinburgh (UK, 1990), Guelph (Canada, 1994), Armidale (Australia, 1998), Montpellier (France, 2002), Belo Horizonte (Brazil, 2006) and Leipzig (Germany, 2010).
Kogelman, L. J. A., Pant, S. D., Karjalainen, J., Franke, L., Fredholm, M., & Kadarmideen, H. N. (2014). Systems genetics analysis of obesity in a porcine model using WISH network method. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production (pp. 1-3) http://www.wcgalp.org/system/files/proceedings/2014/systems-genetics-analysis-obesity-porcine-model-using-wish-network-method.pdf