Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle

M Santana, Haja N Kadarmideen, S Pant, P Alexandre, G Oliveira Junior, R C Gomes, Y T Utsunomiya, H H F Neves, J F Garcia, H Fukumasu, J B S Ferraz

Research output: Book chapter/Published conference paperConference paper

Abstract

Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).
Original languageEnglish
Title of host publicationProceedings, 10th World Congress of Genetics Applied to Livestock Production
Pages1-4
Number of pages4
Publication statusPublished - 2014
Event10th World Congress of Genetics Applied to Livestock Production: WCGALP 2014 - Westin Bayshore Conference Center, Vancouver, Canada
Duration: 17 Aug 201422 Aug 2014
https://web.archive.org/web/20140805071635/http://www.wcgalp.com/ (Conference website)
http://www.wcgalp.org/proceedings/2014 (Conference proceedings)

Conference

Conference10th World Congress of Genetics Applied to Livestock Production
CountryCanada
CityVancouver
Period17/08/1422/08/14
OtherThe joint US-Canada organizing committee is proud to welcome you to the 10th World Congress on Genetics Applied to Livestock Production (WCGALP) being held from 17 – 22 August 2014 at the Westin Bayshore Conference Center situated on the bay in the gorgeous city of Vancouver, British Columbia, Canada.

This congress is the premier conference for researchers and professionals involved in genetic improvement of livestock. Delegates from around the world gather every four years to attend the scientific program and network with colleagues. This 10th WGCALP builds from previous successful congresses in Madrid (1974 and 1982), Lincoln (USA, 1986), Edinburgh (UK, 1990), Guelph (Canada, 1994), Armidale (Australia, 1998), Montpellier (France, 2002), Belo Horizonte (Brazil, 2006) and Leipzig (Germany, 2010).
Internet address

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Nellore
zebu
feed conversion
feed intake
phenotype
cattle
aldosterone
proteoglycans
ion transport
average daily gain
dry matter intake
body composition
biochemical pathways
bulls
genes
T-lymphocytes
sodium
genomics
receptors
testing

Cite this

Santana, M., Kadarmideen, H. N., Pant, S., Alexandre, P., Oliveira Junior, G., Gomes, R. C., ... Ferraz, J. B. S. (2014). Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production (pp. 1-4)
Santana, M ; Kadarmideen, Haja N ; Pant, S ; Alexandre, P ; Oliveira Junior, G ; Gomes, R C ; Utsunomiya, Y T ; Neves, H H F ; Garcia, J F ; Fukumasu, H ; Ferraz, J B S. / Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. pp. 1-4
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abstract = "Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).",
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Santana, M, Kadarmideen, HN, Pant, S, Alexandre, P, Oliveira Junior, G, Gomes, RC, Utsunomiya, YT, Neves, HHF, Garcia, JF, Fukumasu, H & Ferraz, JBS 2014, Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. in Proceedings, 10th World Congress of Genetics Applied to Livestock Production. pp. 1-4, 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 17/08/14.

Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. / Santana, M; Kadarmideen, Haja N; Pant, S; Alexandre, P; Oliveira Junior, G; Gomes, R C; Utsunomiya, Y T; Neves, H H F; Garcia, J F; Fukumasu, H; Ferraz, J B S.

Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. p. 1-4.

Research output: Book chapter/Published conference paperConference paper

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T1 - Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle

AU - Santana, M

AU - Kadarmideen, Haja N

AU - Pant, S

AU - Alexandre, P

AU - Oliveira Junior, G

AU - Gomes, R C

AU - Utsunomiya, Y T

AU - Neves, H H F

AU - Garcia, J F

AU - Fukumasu, H

AU - Ferraz, J B S

PY - 2014

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N2 - Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

AB - Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

KW - beef cattle

KW - GWAS

KW - system biology

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M3 - Conference paper

SP - 1

EP - 4

BT - Proceedings, 10th World Congress of Genetics Applied to Livestock Production

ER -

Santana M, Kadarmideen HN, Pant S, Alexandre P, Oliveira Junior G, Gomes RC et al. Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. p. 1-4