Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle

M Santana; Haja N Kadarmideen; S Pant; P Alexandre; G Oliveira Junior; R C Gomes; Y T Utsunomiya; H H F Neves; J F Garcia; H Fukumasu; J B S Ferraz

Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle

M Santana, Haja N Kadarmideen, S Pant, P Alexandre, G Oliveira Junior, R C Gomes, Y T Utsunomiya, H H F Neves, J F Garcia, H Fukumasu, J B S Ferraz

Research output: Book chapter/Published conference paper › Conference paper

Abstract

Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

Original language	English
Title of host publication	Proceedings, 10th World Congress of Genetics Applied to Livestock Production
Pages	1-4
Number of pages	4
Publication status	Published - 2014
Event	10th World Congress of Genetics Applied to Livestock Production: WCGALP 2014 - Westin Bayshore Conference Center, Vancouver, Canada Duration: 17 Aug 2014 → 22 Aug 2014 https://web.archive.org/web/20140805071635/http://www.wcgalp.com/ (Conference website) http://www.wcgalp.org/proceedings/2014 (Conference proceedings)

Conference

Conference	10th World Congress of Genetics Applied to Livestock Production
Country	Canada
City	Vancouver
Period	17/08/14 → 22/08/14
Other	The joint US-Canada organizing committee is proud to welcome you to the 10th World Congress on Genetics Applied to Livestock Production (WCGALP) being held from 17 – 22 August 2014 at the Westin Bayshore Conference Center situated on the bay in the gorgeous city of Vancouver, British Columbia, Canada. This congress is the premier conference for researchers and professionals involved in genetic improvement of livestock. Delegates from around the world gather every four years to attend the scientific program and network with colleagues. This 10th WGCALP builds from previous successful congresses in Madrid (1974 and 1982), Lincoln (USA, 1986), Edinburgh (UK, 1990), Guelph (Canada, 1994), Armidale (Australia, 1998), Montpellier (France, 2002), Belo Horizonte (Brazil, 2006) and Leipzig (Germany, 2010).
Internet address	https://web.archive.org/web/20140805071635/http://www.wcgalp.com/ (Conference website) http://www.wcgalp.org/proceedings/2014 (Conference proceedings)

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Santana, M., Kadarmideen, H. N., Pant, S., Alexandre, P., Oliveira Junior, G., Gomes, R. C., Utsunomiya, Y. T., Neves, H. H. F., Garcia, J. F., Fukumasu, H., & Ferraz, J. B. S. (2014). Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production (pp. 1-4) http://www.wcgalp.org/system/files/proceedings/2014/systems-genetics-investigations-feed-intake-feed-efficiency-and-performance-nellore-bos-indicus.pdf

Santana, M ; Kadarmideen, Haja N ; Pant, S ; Alexandre, P ; Oliveira Junior, G ; Gomes, R C ; Utsunomiya, Y T ; Neves, H H F ; Garcia, J F ; Fukumasu, H ; Ferraz, J B S. / Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. pp. 1-4

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title = "Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle",

abstract = "Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans). ",

keywords = "beef cattle, GWAS, system biology",

author = "M Santana and Kadarmideen, {Haja N} and S Pant and P Alexandre and {Oliveira Junior}, G and Gomes, {R C} and Utsunomiya, {Y T} and Neves, {H H F} and Garcia, {J F} and H Fukumasu and Ferraz, {J B S}",

year = "2014",

language = "English",

pages = "1--4",

booktitle = "Proceedings, 10th World Congress of Genetics Applied to Livestock Production",

note = "10th World Congress of Genetics Applied to Livestock Production : WCGALP 2014 ; Conference date: 17-08-2014 Through 22-08-2014",

url = "https://web.archive.org/web/20140805071635/http://www.wcgalp.com/, http://www.wcgalp.org/proceedings/2014",

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Santana, M, Kadarmideen, HN, Pant, S, Alexandre, P, Oliveira Junior, G, Gomes, RC, Utsunomiya, YT, Neves, HHF, Garcia, JF, Fukumasu, H & Ferraz, JBS 2014, Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. in Proceedings, 10th World Congress of Genetics Applied to Livestock Production. pp. 1-4, 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 17/08/14. <http://www.wcgalp.org/system/files/proceedings/2014/systems-genetics-investigations-feed-intake-feed-efficiency-and-performance-nellore-bos-indicus.pdf>

Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle. / Santana, M; Kadarmideen, Haja N; Pant, S; Alexandre, P; Oliveira Junior, G; Gomes, R C; Utsunomiya, Y T; Neves, H H F; Garcia, J F; Fukumasu, H; Ferraz, J B S.

Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. p. 1-4.

Research output: Book chapter/Published conference paper › Conference paper

TY - GEN

T1 - Systems genetics investigations for feed intake, feed efficiency and performance in Nellore (Bos indicus) Cattle

AU - Santana, M

AU - Kadarmideen, Haja N

AU - Pant, S

AU - Alexandre, P

AU - Oliveira Junior, G

AU - Gomes, R C

AU - Utsunomiya, Y T

AU - Neves, H H F

AU - Garcia, J F

AU - Fukumasu, H

AU - Ferraz, J B S

PY - 2014

Y1 - 2014

N2 - Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

AB - Genome wide association study (GWAS) was performed in 720 Nellore bulls and steers for dry matter intake (DMI), average daily gain (ADG), feed conversion ratio (FCR) and residual feed intake (RFI), using GRAMMAR-Gamma association test. Genes within 50kb flanking regions of SNPs with the highest association with the phenotypes were extracted, and pathway analysis was performed on the KEGG and DAVID databases. Several genomic regions that were significantly associated with phenotypes (p=9.27×10-5) were identified by GWAS. Near these regions, many genes were found for the four phenotypes studied (e.g. ARG2, ATP8A1, KCNJ, PLAG2G7 and ZNF746). The analysis identified three main metabolic pathways that influence the four phenotypes concomitantly. These processes are mainly related to ion transport (aldosterone-regulated sodium reabsorption), body composition (T cell receptor signaling pathway) and control of feed intake (proteoglycans).

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KW - GWAS

KW - system biology

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UR - https://web.archive.org/web/20140805071635/http://www.wcgalp.com/

UR - https://web.archive.org/web/20140123040251/http://www.wcgalp.com:80/call-for-papers

UR - https://asas.confex.com/asas/WCGALP14/webprogram/Paper8439.html

M3 - Conference paper

SP - 1

EP - 4

BT - Proceedings, 10th World Congress of Genetics Applied to Livestock Production

T2 - 10th World Congress of Genetics Applied to Livestock Production

Y2 - 17 August 2014 through 22 August 2014

ER -