TY - JOUR
T1 - The absence of pathological myofibre disarray in the diabetic heart
T2 - is it a paradox?
AU - McLachlan, Craig
AU - Lasker, Shamima
AU - Keramat Ali, Shah M
AU - Wang, Lexin
AU - Jelinek, Herbert
N1 - Imported on 10 Apr 2017 - DigiTool details were: Journal title (773t) = Acta Cardiologica: an international journal of cardiology. ISSNs: 0373-7934;
PY - 2009
Y1 - 2009
N2 - Myofibre disarray in progressive hypertrophic cardiomyopathy (HCM) is a well established pathological cardiac tissue change and thereby represents a biomarker for that condition. On the other hand, in diabetic cardiomyopathy, myofibre disarray historically has been reported not to occur. This is surprising given that many of the pathological, remodelling and mechanical changes that present in the diabetic ventricle are also present in HCM, for example, myocardial stiffness, myocardial hypertrophy, apoptosis, cell slippage, extensive collagen expression and fibrosis. The question therefore begs is the absence of myocyte disarray in the diabetic heart a paradox or simply an oversight?
AB - Myofibre disarray in progressive hypertrophic cardiomyopathy (HCM) is a well established pathological cardiac tissue change and thereby represents a biomarker for that condition. On the other hand, in diabetic cardiomyopathy, myofibre disarray historically has been reported not to occur. This is surprising given that many of the pathological, remodelling and mechanical changes that present in the diabetic ventricle are also present in HCM, for example, myocardial stiffness, myocardial hypertrophy, apoptosis, cell slippage, extensive collagen expression and fibrosis. The question therefore begs is the absence of myocyte disarray in the diabetic heart a paradox or simply an oversight?
M3 - Article
SN - 0373-7934
VL - 64
SP - 267
EP - 268
JO - Acta Cardiologica: an international journal of cardiology
JF - Acta Cardiologica: an international journal of cardiology
IS - 2
ER -