The application of exhaled breath analysis in racing Thoroughbreds and the influence of high intensity exercise and ambient temperature on the concentration of carbon monoxide and pH in exhaled breath.

Michael P. Cathcart, Sandy Love, David G.M. Sutton, Richard J.M. Reardon, Kristopher Hughes

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Analyses of exhaled breath (EB) and exhaled breath condensate (EBC) are non-invasive modalities forassessing the lower airways but these methods have not been applied to Thoroughbred racehorses intraining. The aims of this study were to determine whether EB and EBC could be obtained from Thoroughbredracehorses in the field and to investigate the effects of exercise per se and during different ambienttemperatures and humidity on exhaled concentrations of nitric oxide (eNO), carbon monoxide (eCO) andEBC pH. EB and EBC samples were obtained from 28 Thoroughbred racehorses pre- and post-exercise duringwarm (n = 23) and/or cold (n = 19) ambient temperatures.eNO was detected in 19/84 EB samples. eCO was measured in 39/42 EB samples pre-exercise (median1.3 ppm) and concentrations decreased significantly post-exercise (median 0.8 ppm, P < 0.005) and wereassociated with ambient temperature. EBC pH was 4.51 ± 0.23 pre-exercise and increased significantlypost-exercise (4.79 ± 0.59, P = 0.003). The study documented the collection of EB and EBC from Thoroughbredracehorses in a field setting. Alterations in concentrations of volatile gases and EBC pH occurred inresponse to exercise, and were likely to have been influenced by environmental factors.
Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalVeterinary Journal
Volume197
Issue number2
DOIs
Publication statusPublished - Aug 2013

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