In this study, we describe the development of moleculalry imprinted polymers via the use of synthetic selectophores, chosen as readily prepared and low cost structural analogues with recognition groups in similar three-dimensional arrangements as found in the target molecule. To validate the approach, a comparative study of selectophores related to the polyphenolic compound (E)-resveratrol has been undertaken using traditional and green chemical synthetic approaches. These molecular mimic compounds were employed as polymer templates and also as binding analytes to interrogate the recognition sites associated with the molecularly imprinted polymers.
Danylec, B., Schwarz, L., Harris, S. J., Boysen, R. I., & Hearn, M. T. W. (2015). The application of template Selectophores for the preparation of molecularly imprinted polymers. Molecules, 20, 17601-17613. https://doi.org/10.1016/j.jmir.2015.07.007