Aim: The present study aims to associate erythrocyte aggregation with plasma lipid concentration. Materials and Methods: Ninety-nine participants were divided into two groups: normolipidemic and dyslipidemic. Lipid parameters were measured from serum and erythrocyte aggregation parameters: critical stress and critical time were measured from whole blood. Data were analyzed using IBS SPSS statistics software. Results: Erythrocyte aggregation was higher in the dyslipidemic group when compared with the normolipidemic group. Erythrocyte aggregation was associated with the abnormalities in lipid parameters, with the association of HDL-cholesterol and triglyceride being stronger than that of LDL-cholesterol and total cholesterol. Conclusion: The strong association of triglyceride and HDL-cholesterol with erythrocyte aggregation emphasizes the role of these lipids in the cardiovascular system.