The compatibility of multiple intravenous (IV) drugs administered simultaneously

Suci Hanifah

    Research output: ThesisDoctoral Thesis

    14615 Downloads (Pure)


    Multiple IV drug administration in one route often cannot be avoided in critical care as the need for various drugs is higher than the amount of venous access. Thus, incompatibility is likely to be prone to error in critical care, particularly in children. Even though the reported prevalence was less than 25%, which was lower than for other common errors, incompatibility was often less recognised and more liable to be harmful with fatal effects. However, the information available on compatibility in the literature often cannot be applied in the critical care setting due to: dissimilarities in the characteristics of the formulation; information only referring to testing between two drugs; and most studies having been performed using the static approach. In Indonesia, incompatibility is very much under-studied. Thus, this research aims firstly to identify the potential problem of incompatibility. It then conducts a controlled in vitro study, mimicking the situation in clinical practice to validate the potential incompatibility and to assess strategies for minimising incompatibility in the common cases of patients in the Paediatric Intensive Care Unit (PICU), Sardjito Hospital in Yogyakarta, Indonesia. This research began with identification of the potential problem regarding IV drug compatibility. An observational study was performed using resources including medical records and pharmacy records (1 June 2012'30 September 2013), simple questionnaires for nurses/medical doctors and bedside observation to identify the potential problem which, if often encountered, would require urgent study. This step suggested the need to confirm the compatibility of common infusions (analgesics, sedatives and inotropes) when these were reconstituted in a syringe. In addition, these infusions were set in 'a typical patient model': three infusions were set into one peripheral line connected with threeway stopcocks and a Y-connector, and injected with various bolus and intermittent
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Charles Sturt University
    • Ball, Patrick, Principal Supervisor
    • Kennedy, Ross, Co-Supervisor
    Award date16 Mar 2016
    Place of PublicationAustralia
    Publication statusPublished - 2016


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