McArdle's disease is a medical condition where the absence of glycogen phosphorylase protein in skeletal muscle causes symptoms of exercise intolerance. In the past, diagnosis of McArdle's disease was suggested by high levels of plasma creatine kinase and also by the failure of lactate levels to rise in the ischaemic forearm test. This diagnosis was then confirmed by a negative histochemical staining for phosphorylase activity in a muscle biopsy. Less invasive procedures are also currently used in addition to these tests. This review examines the different methods used to diagnose McArdle's disease and discusses various approaches in the management of the disease.
|Number of pages||7|
|Journal||Australian Journal of Medical Science|
|Publication status||Published - 2004|