The diagnosis of renal osteodystrophy: A comparison of Technetium-99m-pyrophosphate bone scintigraphy with other techniques

E. M. Hodson, R. B. Howman-Giles, G. Bautovich, E. E. Hills, K. Sherbon, B. D. Bach, J. S. Horvath, D. J. Tiller

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    Abstract

    In order to determine the place of Technetium-99m-pyrophosphate bone scintigraphy in the assessment of renal osteodystrophy, 17 patients with chronic renal failure requiring hemodialysis underwent bone scans and these were compared to results of biochemical, radiological and histologic studies. Bone histology was abnormal in all patients with most having evidence of osteomalacia and hyperparathyroid bone disease. Using semi-quantitative scan scores and regional bone-standard ratios, isotope uptake was increase in 16 patients, while 15 had elevated alkaline phosphatase levels and 7 had X-ray changes. An osteoid-osteoclast index combining histological osteomalacia and hyperparathyroid bone disease was derived and was found to correlate more closely with alkaline phosphatase and parathyroid hormone levels than with scan parameters. It was concluded that bone scans did not provide therapeutically useful information that could not be obtained from biochemical and radiological studies. It appeared that only bone histology could differentiate osteomalacia and hyperparathyroid bone disease.

    Original languageEnglish
    Pages (from-to)24-28
    Number of pages5
    JournalClinical Nephrology
    Volume16
    Issue number1
    Publication statusPublished - 21 Sep 1981

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    Hodson, E. M., Howman-Giles, R. B., Bautovich, G., Hills, E. E., Sherbon, K., Bach, B. D., Horvath, J. S., & Tiller, D. J. (1981). The diagnosis of renal osteodystrophy: A comparison of Technetium-99m-pyrophosphate bone scintigraphy with other techniques. Clinical Nephrology, 16(1), 24-28.