The effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy

Tara Rosewall, Andrew J. Bayley, Peter Chung, Lisa W. Le, Jason Xie, Siddhartha Baxi, Charles N. Catton, Geoffrey Currie, Janelle Wheat, Michael Milosevic

Research output: Contribution to journalArticle

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Abstract

Purpose To quantify the effect of delineation method on bladder DVH, observer variability (OV) and contouring time for prostate IMRT plans. Materials and methods Planning CT scans and IMRT plans of 30 prostate cancer patients were anonymized. For 20 patients, 1 observer delineated the bladder using 9 methods. The effect of delineation method on the DVH curve, discrete dose levels and delineation time was quantified. For the 10 remaining CTs, 6 observers delineated bladder wall using 4 methods. Observer-based volume variation and intraclass correlation coefficient (ICC) were used to describe the dosimetric effects of OV. Results Manual delineation of the bladder wall (BW_m) was significantly slower than any other method (mean: 20 min vs. '13 min) and the dosimetric effect of OV was significantly larger (V70 Gy ICC: 0.78 vs. 0.98). Only volumes created using a 2.5 mm contraction from the outer surface, and a method providing a consistent wall volume, showed no notable dosimetric differences from BW_m in both absolute and relative volume. Conclusions Automatic contractions from the outer surface provide quicker, more reproducible and reasonably accurate substitutes for BW_m. The widespread use of automatic contractions to create a bladder wall volume would assist in the consistent application of IMRT dose constraints and the interpretation of reported dose.
Original languageEnglish
Pages (from-to)479-485
Number of pages7
JournalRadiotherapy and Oncology
Volume101
Issue number3
DOIs
Publication statusPublished - Dec 2011

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Intensity-Modulated Radiotherapy
Prostate
Urinary Bladder
Prostatic Neoplasms

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Rosewall, Tara ; Bayley, Andrew J. ; Chung, Peter ; Le, Lisa W. ; Xie, Jason ; Baxi, Siddhartha ; Catton, Charles N. ; Currie, Geoffrey ; Wheat, Janelle ; Milosevic, Michael. / The effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy. In: Radiotherapy and Oncology. 2011 ; Vol. 101, No. 3. pp. 479-485.
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The effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy. / Rosewall, Tara; Bayley, Andrew J.; Chung, Peter; Le, Lisa W.; Xie, Jason; Baxi, Siddhartha; Catton, Charles N.; Currie, Geoffrey; Wheat, Janelle; Milosevic, Michael.

In: Radiotherapy and Oncology, Vol. 101, No. 3, 12.2011, p. 479-485.

Research output: Contribution to journalArticle

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T1 - The effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy

AU - Rosewall, Tara

AU - Bayley, Andrew J.

AU - Chung, Peter

AU - Le, Lisa W.

AU - Xie, Jason

AU - Baxi, Siddhartha

AU - Catton, Charles N.

AU - Currie, Geoffrey

AU - Wheat, Janelle

AU - Milosevic, Michael

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N2 - Purpose To quantify the effect of delineation method on bladder DVH, observer variability (OV) and contouring time for prostate IMRT plans. Materials and methods Planning CT scans and IMRT plans of 30 prostate cancer patients were anonymized. For 20 patients, 1 observer delineated the bladder using 9 methods. The effect of delineation method on the DVH curve, discrete dose levels and delineation time was quantified. For the 10 remaining CTs, 6 observers delineated bladder wall using 4 methods. Observer-based volume variation and intraclass correlation coefficient (ICC) were used to describe the dosimetric effects of OV. Results Manual delineation of the bladder wall (BW_m) was significantly slower than any other method (mean: 20 min vs. '13 min) and the dosimetric effect of OV was significantly larger (V70 Gy ICC: 0.78 vs. 0.98). Only volumes created using a 2.5 mm contraction from the outer surface, and a method providing a consistent wall volume, showed no notable dosimetric differences from BW_m in both absolute and relative volume. Conclusions Automatic contractions from the outer surface provide quicker, more reproducible and reasonably accurate substitutes for BW_m. The widespread use of automatic contractions to create a bladder wall volume would assist in the consistent application of IMRT dose constraints and the interpretation of reported dose.

AB - Purpose To quantify the effect of delineation method on bladder DVH, observer variability (OV) and contouring time for prostate IMRT plans. Materials and methods Planning CT scans and IMRT plans of 30 prostate cancer patients were anonymized. For 20 patients, 1 observer delineated the bladder using 9 methods. The effect of delineation method on the DVH curve, discrete dose levels and delineation time was quantified. For the 10 remaining CTs, 6 observers delineated bladder wall using 4 methods. Observer-based volume variation and intraclass correlation coefficient (ICC) were used to describe the dosimetric effects of OV. Results Manual delineation of the bladder wall (BW_m) was significantly slower than any other method (mean: 20 min vs. '13 min) and the dosimetric effect of OV was significantly larger (V70 Gy ICC: 0.78 vs. 0.98). Only volumes created using a 2.5 mm contraction from the outer surface, and a method providing a consistent wall volume, showed no notable dosimetric differences from BW_m in both absolute and relative volume. Conclusions Automatic contractions from the outer surface provide quicker, more reproducible and reasonably accurate substitutes for BW_m. The widespread use of automatic contractions to create a bladder wall volume would assist in the consistent application of IMRT dose constraints and the interpretation of reported dose.

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