The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report

Robert M. Kirberger; Nicolette Cassel; Ann Carstens; Amelia Goddard

doi:10.1186/1751-0147-54-47

The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report

Robert M. Kirberger, Nicolette Cassel, Ann Carstens, Amelia Goddard

Agricultural, Environmental and Veterinary Sciences

University of Pretoria

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

5 Downloads (Pure)

Abstract

BACKGROUND: Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.METHODS: This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.RESULTS: Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.CONCLUSIONS: No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

Original language	English
Article number	47
Pages (from-to)	1-10
Journal	Acta Veterinaria Scandinavica
Volume	54
DOIs	https://doi.org/10.1186/1751-0147-54-47
Publication status	Published - 01 Jan 2012

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43703262 Published articleFinal published version, 590 KBLicence: CC BY

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title = "The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report",

abstract = "BACKGROUND: Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.METHODS: This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.RESULTS: Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.CONCLUSIONS: No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.",

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AU - Carstens, Ann

AU - Goddard, Amelia

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N2 - BACKGROUND: Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.METHODS: This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.RESULTS: Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.CONCLUSIONS: No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

AB - BACKGROUND: Contrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.METHODS: This prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6-8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.RESULTS: Only GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.CONCLUSIONS: No clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

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The effects of repeated intravenous iohexol administration on renal function in healthy beagles - a preliminary report

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