The impact of anemia on the prognosis of chronic heart failure: a meta-analysis and systemic review

Sheng-wen He, Lexin Wang

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)
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Abstract

Objective: The aim of this study was to assess the impact of anemia on the clinical outcomes of chronic heart failure (CHF) by a meta-analysis and systemic review of published literatures.Methods: Twenty published English language articles were selected from Medline, PubMed and ISI Database. Clinical data were extracted, pooled and analyzed with a fixed or random effects model.Results: A total of 97,699 patients with CHF were identified from the published studies. Meta-analysis of these studies indicated that anemia is associated with a higher risk for death (relative risk or RR, 1.66, P<0.0001). In addition, anemic patients had more advanced NYHA class (NYHA III-IV, RR, 1.35, P<0.0001) and lower left ventricular ejection fraction (weight mean difference or WMD, -0.53, P<0.0001) than in non-anemic patients. Systemic review also revealed that the severity of anemia is closely related to the rate of mortality and hospitalization for heart failure.Conclusions: Anemia is associated with an increased risk of mortality and rate of hospitalization for heart failure. Anemia is an independent risk factor for adverse outcomes in patients with CHF.
Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalCongestive Heart Failure
Volume15
Issue number3
DOIs
Publication statusPublished - Jan 2009

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