TY - JOUR
T1 - The impact of anemia on the prognosis of chronic heart failure
T2 - a meta-analysis and systemic review
AU - He, Sheng-wen
AU - Wang, Lexin
N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = Jan 2009; Journal title (773t) = Congestive Heart Failure. ISSNs: 1527-5299;
PY - 2009/1
Y1 - 2009/1
N2 - Objective: The aim of this study was to assess the impact of anemia on the clinical outcomes of chronic heart failure (CHF) by a meta-analysis and systemic review of published literatures.Methods: Twenty published English language articles were selected from Medline, PubMed and ISI Database. Clinical data were extracted, pooled and analyzed with a fixed or random effects model.Results: A total of 97,699 patients with CHF were identified from the published studies. Meta-analysis of these studies indicated that anemia is associated with a higher risk for death (relative risk or RR, 1.66, P<0.0001). In addition, anemic patients had more advanced NYHA class (NYHA III-IV, RR, 1.35, P<0.0001) and lower left ventricular ejection fraction (weight mean difference or WMD, -0.53, P<0.0001) than in non-anemic patients. Systemic review also revealed that the severity of anemia is closely related to the rate of mortality and hospitalization for heart failure.Conclusions: Anemia is associated with an increased risk of mortality and rate of hospitalization for heart failure. Anemia is an independent risk factor for adverse outcomes in patients with CHF.
AB - Objective: The aim of this study was to assess the impact of anemia on the clinical outcomes of chronic heart failure (CHF) by a meta-analysis and systemic review of published literatures.Methods: Twenty published English language articles were selected from Medline, PubMed and ISI Database. Clinical data were extracted, pooled and analyzed with a fixed or random effects model.Results: A total of 97,699 patients with CHF were identified from the published studies. Meta-analysis of these studies indicated that anemia is associated with a higher risk for death (relative risk or RR, 1.66, P<0.0001). In addition, anemic patients had more advanced NYHA class (NYHA III-IV, RR, 1.35, P<0.0001) and lower left ventricular ejection fraction (weight mean difference or WMD, -0.53, P<0.0001) than in non-anemic patients. Systemic review also revealed that the severity of anemia is closely related to the rate of mortality and hospitalization for heart failure.Conclusions: Anemia is associated with an increased risk of mortality and rate of hospitalization for heart failure. Anemia is an independent risk factor for adverse outcomes in patients with CHF.
KW - Open access version available
KW - Anemia
KW - Chronic heart failure
KW - Meta-analysis
KW - Mortality
KW - Prognosis
U2 - 10.1111/j.1751-7133.2008.00030.x
DO - 10.1111/j.1751-7133.2008.00030.x
M3 - Article
SN - 1527-5299
VL - 15
SP - 123
EP - 130
JO - Congestive Heart Failure
JF - Congestive Heart Failure
IS - 3
ER -