The impact of generator ingrowth time on bone scan quality

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This investigation evaluated the impact of the increased presence of technetium-99 in molybdenum-99/technetium-99m generator elute following a long generator ingrowth time on bone scan image quality.Methods: The study was a prospective analysis of consecutive bone scans performed on either Monday (72 hour ingrowth) or Tuesday (24 hour ingrowth) of a standard working week in a single nuclear medicine department. Regions of interest (ROI) were drawn to obtain a bone to soft tissue ratio of radiopharmaceutical accumulation in 92 patients. Age, gender, injection to scan time, and bone to soft tissue ratio of the two study groups were compared.Results: All three variables, age (P = 0.634), gender (P = 0.827), injection to scan time (P = 0.386) demonstrated no statistically significant difference between the Monday and Tuesday cohorts. While the mean bone to sift tissue ratio for the Monday group was lower (2.15) than the Tuesday group (2.30), no statistically significant difference was noted (P = 0.213).Conclusion: No statistical significance between the bone to soft tissue ratios between 24 and 72 hours generator ingrowth time was shown despite evidence of an improvement on Tuesday. Further investigation using a larger, multi-centre trial is recommended.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInternet Journal of Nuclear Medicine
Issue number1
Publication statusPublished - 2008


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