The influence of pharmacological autonomic blockades on multi-scale measures of heart rate variability

Faezeh Marzbanrad, C. K. Karmakar, A. H. Khandoker, M. Palaniswami, T. Moritani, H. F. Jelinek

Research output: Book chapter/Published conference paperConference paper

Abstract

Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multi-scale measures with respect to changes in parasympathetic and sympathetic activity.
Original languageEnglish
Title of host publicationEMBEC and NBC 2017
Subtitle of host publicationJoint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics
EditorsHannu Eskola, Outi Vaisanen, Jari Viik, Jari Hyttinen
PublisherSpringer-Verlag London Ltd.
Pages462-465
Number of pages4
Volume65
ISBN (Electronic)9789811051227
ISBN (Print)9789811051210
DOIs
Publication statusPublished - 2018
EventEMBEC & NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) - Tampere Hall, Tampere, Finland
Duration: 11 Jun 201715 Jun 2017
https://embec2017.org/ (Conference website)
https://link.springer.com/book/10.1007/978-981-10-5122-7 (Conference proceedings)

Publication series

NameIFMBE Proceedings
PublisherSpringer Nature
Volume65
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

ConferenceEMBEC & NBC 2017
CountryFinland
CityTampere
Period11/06/1715/06/17
OtherIt is our pleasure to invite you to the joint conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), in Tampere, Finland, in June 2017. These two long running conferences are now combined for the first time with aim to build a truly cross-discipline conference. We aim to present all traditional BMES and BME areas, but also highlight new emerging fields, such as tissue engineering, bioinformatics, biosensing, neurotechnology, additive manufacturing technologies for medicine and biology, and bioimaging, to name a few. Moreover, we will emphasize the role of education, translational research, and commercialization.The scientific and social program at EMBEC’17 & NBC’17 provides an excellent platform for engineers, physicists, biologists, and clinical experts to enhance our knowledge and scientific achievements by bridging complementary disciplines and new findings into an interactive and attractive forum.
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    Marzbanrad, F., Karmakar, C. K., Khandoker, A. H., Palaniswami, M., Moritani, T., & Jelinek, H. F. (2018). The influence of pharmacological autonomic blockades on multi-scale measures of heart rate variability. In H. Eskola, O. Vaisanen, J. Viik, & J. Hyttinen (Eds.), EMBEC and NBC 2017: Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (Vol. 65, pp. 462-465). (IFMBE Proceedings; Vol. 65). Springer-Verlag London Ltd.. https://doi.org/10.1007/978-981-10-5122-7_116