TY - JOUR
T1 - The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.
AU - Sundra, T.M.
AU - Harrison, J.L.
AU - Lester, G.D.
AU - Raidal, Sharanne
AU - Phillips, J.K.
N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = December, 2012; Journal title (773t) = Research in Veterinary Science. ISSNs: 0034-5288;
PY - 2012/12
Y1 - 2012/12
N2 - The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (100mg), hyoscine (120mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect ('120min). Both drugs elevated HR relative to the control baseline period (P<0.05), with the effects of propantheline again being of longer duration. HRV analysis indicated that propantheline suppressed Total Power (P<0.05), and both the high frequency (HF) and low frequency (LF) components of the power spectral analysis for up to 60-90min post treatment. Hyoscine had no effect on HRV Total Power but reduced the HF component for 30min after drug injection. Time domain variables correlated with Total Power and HF data (P<0.01). The marked effect of these compounds on parasympathetic control of cardiac and GIT function in normal horses should be taken into consideration when evaluating a clinical response to these agents.
AB - The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (100mg), hyoscine (120mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect ('120min). Both drugs elevated HR relative to the control baseline period (P<0.05), with the effects of propantheline again being of longer duration. HRV analysis indicated that propantheline suppressed Total Power (P<0.05), and both the high frequency (HF) and low frequency (LF) components of the power spectral analysis for up to 60-90min post treatment. Hyoscine had no effect on HRV Total Power but reduced the HF component for 30min after drug injection. Time domain variables correlated with Total Power and HF data (P<0.01). The marked effect of these compounds on parasympathetic control of cardiac and GIT function in normal horses should be taken into consideration when evaluating a clinical response to these agents.
U2 - 10.1016/j.rvsc.2012.05.003
DO - 10.1016/j.rvsc.2012.05.003
M3 - Article
SN - 0034-5288
VL - 93
SP - 1426
EP - 1433
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 3
ER -