The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.

T.M. Sundra, J.L. Harrison, G.D. Lester, Sharanne Raidal, J.K. Phillips

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (100mg), hyoscine (120mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect ('120min). Both drugs elevated HR relative to the control baseline period (P<0.05), with the effects of propantheline again being of longer duration. HRV analysis indicated that propantheline suppressed Total Power (P<0.05), and both the high frequency (HF) and low frequency (LF) components of the power spectral analysis for up to 60-90min post treatment. Hyoscine had no effect on HRV Total Power but reduced the HF component for 30min after drug injection. Time domain variables correlated with Total Power and HF data (P<0.01). The marked effect of these compounds on parasympathetic control of cardiac and GIT function in normal horses should be taken into consideration when evaluating a clinical response to these agents.
Original languageEnglish
Pages (from-to)1426-1433
Number of pages8
JournalResearch in Veterinary Science
Volume93
Issue number3
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Propantheline
parasympatholytics
Parasympatholytics
gastrointestinal motility
Gastrointestinal Motility
Horses
heart rate
Heart Rate
Scopolamine Hydrobromide
gastrointestinal system
horses
Gastrointestinal Tract
drug injection
duration
bromides
spectral analysis
Butylscopolammonium Bromide
drugs
Pharmaceutical Preparations
Electrocardiography

Cite this

Sundra, T.M. ; Harrison, J.L. ; Lester, G.D. ; Raidal, Sharanne ; Phillips, J.K. / The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses. In: Research in Veterinary Science. 2012 ; Vol. 93, No. 3. pp. 1426-1433.
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The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses. / Sundra, T.M.; Harrison, J.L.; Lester, G.D.; Raidal, Sharanne; Phillips, J.K.

In: Research in Veterinary Science, Vol. 93, No. 3, 12.2012, p. 1426-1433.

Research output: Contribution to journalArticle

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