This research examined whether sense of belonging in the community and sexual orientation were associated with dysphoria among women. Australian female heterosexuals (n = 202) and lesbians (n = 184) completed the Sense of Belonging Instrument and the Depression, Anxiety, Stress Scales. Results indicated that lesbians experienced a decreased sense of belonging and more dysphoria compared with heterosexual women. Subsequent analyses indicated that sense of belonging to the community mediated the relation between sexual orientation and dysphoria. In addition, sexual orientation moderated the relation between sense of belonging and dysphoria. It appears that the enhancement of lesbians' sense of belonging in the community would be associated with a reduction in dysphoria.