The potential of lupin as a functional food for the prevention of diabetes and pancreatic cancer

Kishor Mazumder, Kenneth Chinkwo, Asgar Farahnaky, Philip Kerr

Research output: Other contribution to conferenceAbstract


In Australia, lupin has until relatively recently been used solely as a feed stock and for soil nitrogen replenishment. With the world demand for nutritious plant-based foods for human consumption continually increasing, and more especially in the light of pulse crops for the export and domestic markets, it is appropriate to evaluate lupins for both safety and functional characteristics. We examined the chemistry and some biological activities of the seed coats (methanol extract) and de-hulled lupin flours (trichloroacetic acid [TCA] extract) of six cultivars of Lupinus angustifolius and three cultivars of L. albus. Five of the seed coat extracts (two L. angustifolius and three L. albus) were found to induce apoptosis in MIA PaCa-2 (human pancreas carcinoma). All 6 L. angustifolius seed coat extracts inhibited α-glucosidase action in vitro. The TCA extracts contained quinolizidine alkaloids at levels below human toxicity but with potential health benefits. Human studies which have reported some of these alkaloids as possessing ‘antidiabetic’ activity. In all, our results support the notion that lupin is potentially a nutraceutical and functional food of note.
Original languageEnglish
Number of pages1
Publication statusPublished - 12 Sept 2018
Event68th Australasian Grain Science Conference - Charles Sturt University, Wagga Wagga, Australia
Duration: 10 Sept 201813 Sept 2018 (Conference booklet)


Conference68th Australasian Grain Science Conference
Abbreviated titleGrain Science Transforming our Future
CityWagga Wagga
Internet address


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