BackgroundThis study was designed to evaluate the value of plasma cystatin C in predicting adverse cardiac events after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).MethodsA total of 605 patients (404 male, mean age 60.4 ± 10.6 years) with ACS underwent successful PCI. Patients were divided into 4 groups according to the level of cystatin C, which was measured before the PCI: Q1 (<1.02 mg/L), Q2 (1.02-1.16 mg/L), Q3 (1.17-1.34 mg/L), and Q4 ('1.35 mg/L).ResultsAfter a follow-up of 14.3 ± 1.7 months, the incidence of mortality, nonfatal myocardial infarction, and target lesion revascularization in the Q2, Q3, and Q4 groups was higher than in the Q1 group (P < .001). The incidence of heart failure in the Q3 and Q4 groups was higher than in the Q1 group (P < .05). Multivariate Cox regression analysis showed that cystatin C elevation was an independent predictor of major adverse cardiac events. The cumulative survival rate of the Q3 and Q4 groups was lower than in the Q1 group (P < .001).ConclusionHigh plasma cystatin C concentration is an independent predictor of major adverse cardiac events in patients with ACS treated with PCI.
|Number of pages||7|
|Journal||Heart and Lung: Journal of Acute and Critical Care|
|Publication status||Published - 2012|
Sun, T-W., Xu, Q-Y., Yao, H-M., Zhang, X-J., Wu, Q., Zhang, J-Y., Li, L., Zhang, Y-Z., Kan, Q-C., Guan, F-X., & Wang, L. (2012). The predictive value of plasma cystatin C for acute coronary syndrome treated with percutaneous coronary intervention. Heart and Lung: Journal of Acute and Critical Care, 41(5), 456-62. https://doi.org/10.1016/j.hrtlng.2012.04.007