The predictive value of plasma cystatin C for acute coronary syndrome treated with percutaneous coronary intervention

T.-W. Sun, Q.-Y. Xu, H.-M. Yao, X.-J. Zhang, Q.. Wu, J.-Y. Zhang, L. Li, Y.-Z. Zhang, Q.-C. Kan, F.-X. Guan, Lexin Wang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

BackgroundThis study was designed to evaluate the value of plasma cystatin C in predicting adverse cardiac events after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).MethodsA total of 605 patients (404 male, mean age 60.4 ± 10.6 years) with ACS underwent successful PCI. Patients were divided into 4 groups according to the level of cystatin C, which was measured before the PCI: Q1 (<1.02 mg/L), Q2 (1.02-1.16 mg/L), Q3 (1.17-1.34 mg/L), and Q4 ('1.35 mg/L).ResultsAfter a follow-up of 14.3 ± 1.7 months, the incidence of mortality, nonfatal myocardial infarction, and target lesion revascularization in the Q2, Q3, and Q4 groups was higher than in the Q1 group (P < .001). The incidence of heart failure in the Q3 and Q4 groups was higher than in the Q1 group (P < .05). Multivariate Cox regression analysis showed that cystatin C elevation was an independent predictor of major adverse cardiac events. The cumulative survival rate of the Q3 and Q4 groups was lower than in the Q1 group (P < .001).ConclusionHigh plasma cystatin C concentration is an independent predictor of major adverse cardiac events in patients with ACS treated with PCI.
Original languageEnglish
Pages (from-to)456-62
Number of pages7
JournalHeart and Lung: Journal of Acute and Critical Care
Volume41
Issue number5
DOIs
Publication statusPublished - 2012

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