The proangiogenic potential of mesenchymal stem cells and their therapeutic applications

Nadeeka Darshana Maudella Mudiyanselage, Shiang Yong Lim, Haiying Chen, Shuangfeng Chen, Le xin Wang, Padraig Strappe

Research output: Book chapter/Published conference paperChapter in textbook/reference bookpeer-review

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Mesenchymal stem cells (MSCs) can be isolated from many tissue types and following in vitro culture expansion, large numbers of patient-specific or allogenic cells can be produced for clinical applications. MSCs exhibit anti-inflammatory and immunomodulatory properties and are identified as lacking major histocompatibility complex (MHC) class II molecules. Cellular-based approaches using MSCs to enhance new blood vessel formation have shown promise in preclinical models and preliminary clinical trials. Transplantation of MSCs in vivo has significantly enhanced the formation of new blood vessels and promoted the healing of chronic wounds. The proangiogenic potential of MSCs can be further enhanced through gene delivery such as vascular endothelial growth factor (VEGF) or endothelial nitric oxide synthase (eNOS) providing long-term therapeutic expression. In this chapter, we review recent advances on the isolation and characterization of MSCs and in vivo applications for promoting angiogenesis. Enhancement of angiogenesis is also required for improved healing in myocardial infarction and cerebral ischemia, and the use of MSCs in these areas will also be reviewed. Furthermore, the combination of MSCs with biomaterials has greatly improved their survival and potency with improved vascularization of tissue-engineered constructs and integration within the host. In summary, this chapter provides an overview of both the basic science supporting the proangiogenic properties of MSCs and their translational use.
Original languageEnglish
Title of host publicationMesenchymal stem cells
Subtitle of host publicationIsolation, characterization and applications
EditorsPhuc Van Pham
Place of PublicationHershey, PA. USA
PublisherIntechOpen London
Number of pages22
ISBN (Electronic)9789535136163
ISBN (Print)9789535136156
Publication statusPublished - 29 Nov 2017

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