TY - JOUR
T1 - The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia
AU - Pemberton, Louise A.
AU - Stone, E.
AU - Price, P.
AU - Van Bockxmeer, F.
AU - Brew, B. J.
PY - 2008/10
Y1 - 2008/10
N2 - Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage ≥1 and CD4 counts of <500 cells/μL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.
AB - Objectives: Host genetic factors implicated in AIDS dementia complex (ADC) were studied. Methods: DNA from ADC patients (n = 56), unselected HIV-seropositive patients (n = 112, 171, 185 and 204) and HIV-seronegative controls (n = 204, 60, 60, 96 and 624) were typed for polymorphic loci in genes encoding tumour necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-12 and Apolipoprotein E (ApoE). Diagnosis of ADC was based on neurological symptoms, signs and neuroimaging findings with other causes of dementia excluded. Patients selected had ADC stage ≥1 and CD4 counts of <500 cells/μL. Results: Allele 2 of TNFA-308 was more common in ADC patients compared to HIV-positive or HIV-negative controls (P = 0.005, 0.024). No other differences between ADC patients and control groups were significant. Meta-analyses confirmed these results. Conclusions: This study suggests that TNFA-308 allele 2 or an allele in linkage disequilibrium with this locus influences ADC.
KW - Apo E
KW - HIV-1 associated dementia
KW - IL-1
KW - Polymorphisms
KW - TNF-α
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U2 - 10.1111/j.1468-1293.2008.00614.x
DO - 10.1111/j.1468-1293.2008.00614.x
M3 - Article
C2 - 18631256
AN - SCOPUS:52649163940
SN - 1464-2662
VL - 9
SP - 677
EP - 680
JO - HIV Medicine
JF - HIV Medicine
IS - 8
ER -
