The role of leukemia inhibitory factor receptor signaling in skeletal muscle growth, injury and disease

Liam C. Hunt, Jason White

    Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

    19 Citations (Scopus)


    Cytokines are an incredibly diverse group of secreted proteins with equally diverse functions. The actions of cytokines are mediated by the unique and sometimes overlapping receptors to which the soluble ligands bind. Classified within the interleukin-6 family of cytokines are leukemia inhibitory factor (LIF), oncostatin-M (OSM), cardiotrophin-1 (CT-1) and ciliary neurotrophic factor (CNTF). These cytokines all bind to the leukemia inhibitory factor receptor (LIFR) and gp130, and in some cases an additional receptor subunit, leading to activation of downstream kinases and transcriptional activators. LIFR is expressed on a broad range of cell types and can generate pleiotropic effects. In the context of skeletal muscle physiology, these cytokines have been shown to exert effects on motor neurons, inflammatory and muscle cells. From isolated cells through to whole organisms, manipulations of LIFR signaling cytokines have a wide range of outcomes influencing muscle cell growth, myogenic differentiation, response to exercise, metabolism, neural innervation and recruitment of inflammatory cells to sites of muscle injury. This article will discuss the shared and distinct processes that LIFR cytokines regulate in a variety of experimental models with the common theme of skeletal muscle physiology.
    Original languageEnglish
    Title of host publicationGrowth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease
    EditorsJason White, Gayle Smythe
    Place of PublicationSwitzerland
    Number of pages15
    ISBN (Electronic)9783319275116
    ISBN (Print)9783319275093
    Publication statusPublished - 01 May 2016

    Publication series

    NameAdvances in Experimental Medicine and Biology
    ISSN (Print)0065-2598
    ISSN (Electronic)2214-8019


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