The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease

E.J. Coulson, L. M. May, A. M. Sykes, A.S. Hamlin

    Research output: Contribution to journalArticlepeer-review

    49 Citations (Scopus)

    Abstract

    Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75(NTR)) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Abeta), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.
    Original languageEnglish
    Pages (from-to)317-323
    Number of pages7
    JournalNeuroscientist
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - Aug 2009

    Fingerprint

    Dive into the research topics of 'The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease'. Together they form a unique fingerprint.

    Cite this